Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer

Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8.1 years median follow-up. The Lancet Oncology, Vol. 12(12), Nov 2011, p. 1101-1108.

Regan, M.M., et al.

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(11)70270-4/abstract?rss=yes

Postmenopausal women with hormone receptor-positive early breast cancer have persistent, long-term risk of breast-cancer recurrence and death. Therefore, trials assessing endocrine therapies for this patient population need extended follow-up. We present an update of efficacy outcomes in the Breast International Group (BIG) 1-98 study at 8·1 years median follow-up.

Influence of histology on the effectiveness of adjuvant chemotherapy

Influence of histology on the effectiveness of adjuvant chemotherapy in patients with hormone receptor positive invasive breast cancer. The Breast, Vol. 20(6), Dec 2011, p. 505-509.

Truin, W., et al.

http://www.thebreastonline.com/article/S0960-9776(11)00121-4/abstract

To investigate the effect of adjuvant chemotherapy on long term survival in addition to hormonal therapy in the systemic treatment of hormonal receptor positive breast cancer patients.

Trastuzumab combined to neoadjuvant chemotherapy in patients with HER2-positive breast cancer

Trastuzumab combined to neoadjuvant chemotherapy in patients with HER2-positive breast cancer: A systematic review and meta-analysis. The Breast Vol. 20(6), Dec 2011, p. 485-490.

Valachis, A., et al.

http://www.thebreastonline.com/article/S0960-9776(11)00135-4/abstract

Potentially eligible trials were located through PubMed and Cochrane Library searches and abstracts of major international conferences. The endpoints that we assessed were pathologic complete response (pCR) rate, breast-conserving surgery (BCS) rate and toxicity.

Intraveneous fluid infusion rate in microsurgical breast reconstruction

Intraveneous fluid infusion rate in microsurgical breast reconstruction: Important lessons learned from 354 free flaps. Plastic & reconstructive surgery, Dec 2011, Vol. 128(6), p. 1153-1160.

Zhong, T., et al.

http://journals.lww.com/plasreconsurg/Abstract/2011/12000/Intravenous_Fluid_Infusion_Rate_in_Microsurgical.1.aspx

The purpose of this study was to determine the role of intravenous fluid infusion rate in the development of in-hospital complications in patients undergoing microsurgical breast reconstruction for breast cancer.

Simultaneous scarless contralateral breast augmentation

Simultaneous scarless contralateral breast augmentation during unilateral breast reconstruction using bilateral differentially split DIEP flaps. Plastic & reconstructive surgery, Dec 2011, Vol 128(6), p. 593e-604e.

Huang, J-J., et al.

http://journals.lww.com/plasreconsurg/Abstract/2011/12000/Simultaneous_Scarless_Contralateral_Breast.6.aspx

Simultaneous contralateral augmentation is performed with unilateral breast reconstruction to achieve pleasing and symmetric breast mounds. This prospective study investigated the outcome of simultaneous scarless contralateral augmentation with unilateral breast reconstruction using bilateral differentially split deep inferior epigastric perforator (DIEP) flaps.

The lateral chest wall: A separate aesthetic unit in breast surgery

The lateral chest wall: A separate aesthetic unit in breast surgery. Plastic and reconstructive surgery; Dec 2011, Vol. 128(6), p. 626e - 643e.

Bar-Meir, E.D., et al.

http://journals.lww.com/plasreconsurg/Abstract/2011/12000/The_Lateral_Chest_Wall___A_Separate_Aesthetic_Unit.13.aspx

The lateral chest wall is an aesthetic unit often overlooked in breast surgery. Abnormalities are often seen in candidates for aesthetic and reconstructive breast surgery and in the massive weight loss population. Preoperative evaluation of the lateral chest wall is necessary to address this area properly.

Pertuzumab plus Trastuzumab plus Docetaxel for metastatic breast cancer

Pertuzumab plus Trastuzumab plus Docetaxel for metastatic breast cancer. N Eng J Med, Dec 2011.

Baselga, J., et al.

http://www.nejm.org/doi/full/10.1056/NEJMoa1113216#t=article

The anti–human epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody trastuzumab improves the outcome in patients with HER2-positive metastatic breast cancer. However, most cases of advanced disease eventually progress.

Evedrolimus in postmenopausal hormone-receptor-positive advanced breast cancer

Evedrolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Eng J. Med, Dec 2011

Baselga, J., et al.

http://www.nejm.org/doi/full/10.1056/NEJMoa1109653#t=article

Endocrine therapy is the cornerstone of treatment for patients with hormone-receptor (HR)–positive advanced breast cancer. In postmenopausal patients, aromatase inhibitors (e.g., letrozole and anastrozole) have become the treatment of choice in first-line therapy. Unfortunately, not all patients have a response to first-line endocrine therapy (primary or de novo resistance), and even patients who have a response will eventually relapse (acquired resistance).

Disappearance of a breast prosthesis during Pilates

Disappearance of a breast prosthesis during Pilates. N Eng J Med., 2011, 365:2305

Fong, T.C., and Hoffmann, B.

http://www.nejm.org/doi/full/10.1056/NEJMicm1102594

A 59-year-old woman with a history of breast cancer who underwent bilateral mastectomy and placement of breast prostheses presented for evaluation, reporting that her “body swallowed one of the implants” during a Pilates stretching exercise.

Minor influence of self-selection bias on the effectiveness of breast cancer screening in case-control studies in the Netherlands

Minor influence of self-selection bias on the effectiveness of breast cancer screening in case-control studies in the Netherlands. Journal of medical screening, Sept 2011, Vol. 18(3), p. 142-146

Paap, E., et al.

http://jms.rsmjournals.com/content/18/3/142.short?rss=1

Self-selection bias is considered to be a problem when evaluating the effectiveness of breast cancer service screening in case-control studies. Using the incidence-based mortality method (IBM), a correction factor for the potential influence of self-selection can be derived from a group of non-screened women and a group of not-invited women.

Challenges in mammography Part II: Multimodality of breast augmentation

Challenges in mammography Part II: Multimodality of breast augmention - imaging findings and complications. AJR, Dec 2011, Vol 197(6), p. W1031-W1045

Venkataraman, S. et al.

http://www.ajronline.org/content/197/6/W1031.abstract

Breast augmentation is common throughout the world; however, there is variation in materials and surgical techniques. This review illustrates the mammographic, sonographic, and MRI characteristics of the different types of breast augmentation, including silicone, saline, polyacrylamide gel, and autologous fat augmentation.

Challenges in mammography Part I: Artifacts in digital mammography

Challenges in mammography Part I: Artifacts in digital mammography. AJR, Dec 2011, Vol 197(6), p. W1023-W1030

Geiser, W.R., et al.

http://www.ajronline.org/content/197/6/W1023.abstract?rss=1

Early detection of breast cancer is directly related to the radiologist’s ability to detect abnormalities visible only on mammograms. Artifacts on mammograms reduce image quality and may present clinical and technical difficulties for the radiologist, mammography technologist, medical physicist, and equipment service personnel.

Impact on breast cancer diagnosis in a multidisciplinary unit after the incorporation of mammography digitalization

Impact on breast cancer diagnosis in a multidisciplinary unit after the incorporation of mammography digitalization and computer-aided detection systems. AJR, Dec 2011, Vol 197(6), p. 1492-97.

Romero, C., et al.

http://www.ajronline.org/content/197/6/1492.abstract?rss=1

The purpose of this article is to evaluate the impact on the diagnosis of breast cancer of implementing full-field digital mammography (FFDM) in a multidisciplinary breast pathology unit and, 1 year later, the addition of a computer-aided detection (CAD) system.

The low uptake of breast screening in cities is a major public health issue and be due to organisational factors

The low uptake of breast screening in cities is a major public health issue and may be due to organisational factors: A Census-based record linkage study. The Breast, Oct 2011, Vol. 20(5), p.460-463

Kinnear, H. et al.

http://www.thebreastonline.com/article/PIIS0960977611000993/abstract?rss=yes

Cancer screening uptake is generally lower in UK cities but quantifying city-level effects from causes due to population composition that comprise cities is hampered by data limitations. The reduced uptake of screening in cities is a major public health issue; the effects are large and a large proportion of the population are affected, organisational factors appear to be the primary cause. Strategies to correct this imbalance might help reduce inequalities in health.

Breast cancer after hormone replacement therapy

Breast cancer after hormone replacement therapy: does prognosis differ in preimenopausal and postmenopausal women? The Breast, Oct 2011, Vol. 20(5), p.448-454

A.K. Baumgärtner, AK, et al.

Hormone replacement therapy (HRT) has been associated with higher incidence of breast cancer in postmenopausal women, but it is unclear if breast cancers developing after HRT use have different prognosis. 1053 women with hormone receptor positive non-metastasized breast cancer were analyzed in a retrospective trial, stratifying by HRT use before diagnosis. In this retrospective analysis postmenopausal HRT users seemed to have a better breast cancer prognosis. For perimenopausal HRT users however, a trend towards worse prognosis was found.

Impact of immediate breast reconstruction on breast cancer recurrence and survival

Impact of immediate breast reconstruction on breast cancer recurrence and survival. The Breast, Oct 2011, Vol. 20(5), p.437-443

Nedumpara, T., et al.

The practise of Immediate Breast Reconstruction (IBR) following mastectomy for primary breast cancer is being increasingly adopted. Here the impact of IBR on disease progression and survival was assessed following treatment for invasive breast cancer. 1697 consecutive patients received surgical treatment for operable primary breast cancer between January 1996 and December 2007. Overall, 691 (41%) received mastectomy of whom 136 (20%) underwent IBR (82 Latissimus Dorsi, 54 Subpectoral).The effect of IBR on overall survival, local and distant recurrence was analysed in all patients studied and also separately within subgroups defined by Nottingham Prognostic Index (NPI) scores.

Radiofrequency ablation of early breast cancer followed by delayed surgical resection

Radiofrequency ablation of early breast cancer followed by delayed surgical resection: A promising alternative to breast-conserving surgery. The Breast, Oct 2011, Vol. 20(5), p.431-436

Ohtani, S., et al.

To examine the radiofrequency ablation (RFA) reliability in early breast cancer, we performed RFA followed by delayed surgical resection on 41 patients with invasive or non-invasive breast carcinoma less than 2 cm. MRI scans were obtained before ablation and resection. Excised specimens were examined pathologically by haematoxylin-eosin and nicotinamide adenine dinucleotide-diaphorase staining. 40 patients completed 1 RFA session, which was sufficient to achieve complete tumour cell death. Overall complete ablation rate was 87.8% (36/41). There were no treatment-related complications other than that of a superficial burn in 1 case. After RFA, the tumour was no longer enhanced on MRI in 25/26 (96.2%) cases. Residual cancer, which was suspected on MRI in 1 case, was confirmed pathologically. MRI could be an applicable modality to evaluate therapeutic effect. RFA could be an alternate local treatment option to breast-conserving surgery for early breast cancer.

Psychological impact of recall on women with BRCA mutations undergoing MRI surveillance

Psychological impact of recall on women with BRCA mutations undergoing MRI surveillance. The Breast, Oct 2011, Vol. 20(5), p.424-430

Spiegel, TN, et al.

http://www.thebreastonline.com/article/PIIS0960977611000944/abstract?rss=yes

The addition of magnetic resonance imaging (MRI) to mammography for surveillance of women with BRCA mutations significantly increases sensitivity but lowers specificity. This study aimed to examine whether MRI surveillance, and particularly recall, is associated with increased anxiety, depression, or breast cancer worry/distress. While breast MRI surveillance did not have a detrimental psychological impact on women with a BRCA1 or BRCA2 mutation, recalling these very high-risk women for further imaging after a false positive MRI scan temporarily increased their global anxiety.

Calpastatin is associated with lymphovascular invasion in breast cancer

Calpastatin is associated with lympovascular invasion in breast cancer. The Breast, Oct 2011, Vol. 20(5), p. 413-418

Storr, SJ, et al.

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to examine genes and proteins involved in lymphovascular invasion (LVI) to understand the mechanisms of this key disease process. The data supports the hypothesis that calpastatin may play a role in regulating the initial metastatic dissemination of breast cancer.

Leiomyosarcoma of the breast

Leiomyosarcoma of the breast: A case report and review of the literature about therapeutic management. The Breast, Oct 2011, Vol 20(5), p.389-393

Fujita, N., et al.


A leiomyosarcoma of the breast in an 18-year-old female. No specific treatment has been established. In order to clarify appropriate therapeutic management methods, the limited data available from our and previous case reports were assessed. A leiomyosarcoma of the breast must be excised with a negative margin. If the tumor size is large and an adequate margin, greater than 3-cm margin around the excised tumor, is not achieved due to anatomical constraints, radiotherapy may be indicated.

Reduction mammaplasty, obesity and massive weight loss

Reduction mammaplasty, obesity and massive weight loss: Temporal relationships of satisfaction with breast contour. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 643-650.

Coriddi, M., et al.

http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/Reduction_Mammaplasty,_Obesity,_and_Massive_Weight.3.aspx

Reduction mammaplasty is often performed on obese women. With the rise in bariatric procedures, secondary changes to breast contour are increasing. This study aims to investigate the temporal relationships of breast contour satisfaction with weight status.

Anaplastic large cell lymphoma and breast implants

Anaplastic large cell lymphoma and breast implants: Results from a structured expert consultation process. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 629-639.

Kim, B., et al.

http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/Anaplastic_Large_Cell_Lymphoma_and_Breast.1.aspx

There are increasing concerns about a possible association between anaplastic large cell lymphoma (ALCL) and breast implants. The authors conducted a structured expert consultation process to evaluate the evidence for the association, its clinical significance, and a potential biological model based on their interpretation of the published evidence.

A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast

A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 112e-118e.

Carty, MJ, et al.

http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/A_Patient_Death_Attributable_to_Implant_Related.5.aspx

Implant-related primary anaplastic large cell lymphoma (ALCL) of the breast is a rare clinical entity. With increasing attention being paid to this disease, most cases reported to date in the literature have demonstrated indolent clinical courses responsive to explantation, capsulectomy, chemotherapy, and/or radiotherapy. The authors describe a case of bilateral implant-related primary ALCL of the breast that proved refractory to both standard and aggressive interventions, ultimately resulting in patient death secondary to disease progression. The authors situate this case in the context of the current state of knowledge regarding implant-related primary ALCL of the breast and suggest that this entity is generally, but not universally, indolent in nature.

Anaplastic large T-cell lymphoma and breast implants

Anaplastic large T-cell lymphoma and breast implants: A review of the literature. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 651-661.

Jewell, M., et al.

http://journals.lww.com/plasreconsurg/Abstract/2011/09000/Anaplastic_Large_T_Cell_Lymphoma_and_Breast.4.aspx

Anecdotal reports and one case-control study suggested an association, without evidence of causation, between breast implants and anaplastic lymphoma kinase–negative anaplastic large T-cell lymphoma (ALCL), a rare non-Hodgkin's lymphoma. This review summarizes the published evidence, including case reports and epidemiologic studies.

Extending the age range for breast screening in England

Extending the age range for breast screening in England: pilot study to assess the feasibility and acceptability of randomization. Journal of medical screening, June 2011, vol. 18(2), p. 96-102.

Moser, K., et al.

http://jms.rsmjournals.com/content/18/2/96.short?rss=1

To assess the feasibility and acceptability of randomizing the phased introduction of the extension of the invited age range in the National Health Service (NHS) Breast Screening Programme in England from 50–70 to 47–73 years.

Screening outcomes in women over age 70 who self-refer in the NHSBSP in England

Screening outcomes in women over age 70 who self-refer in the NHSBSP in England. Journal of medical screening, June 2011, vol. 18(2), p. 291-295.

Bennett, RL, Moss, SM.

http://jms.rsmjournals.com/content/18/2/91.short?rss=1

The NHS breast screening programme (NHSBSP) in England currently invites women aged 50–70 every three years. Whilst screening is acknowledged as efficacious for women aged 50–69, several countries routinely invite women up to the age of 74. The NHSBSP in England is beginning to invite women up to the age of 73. Although the incidence of breast cancer increases with age, the possible benefits of screening older women must be balanced against shorter life expectancies and possible overdiagnosis. In England women can self-refer after reaching the invitation upper age limit.

Breast surface radiation dose during coronary CT angiography

Breast surface radiation dose during coronary CT angiography: Reduction by breast displacement and lead shielding. AJR, August 2011, vol. 197(2), p. 367-373.

Foley, SJ, et al.

http://www.ajronline.org/content/197/2/367.abstract?rss=1

The purpose of this study was to prospectively evaluate the effect of cranial breast displacement and lead shielding on in vivo breast surface radiation dose in women undergoing coronary CT angiography.

Microcalcifications around a collegen-based breast biopsy marker: complication of biopsy with a percutaneous marking system

Microcalcifications around a collegen-based breast biopsy marker: complication of biopsy with a percutaneous marking system. AJR, August 2011, vol. 197(2), p.W353 - W357

Trop, I., et al.

http://www.ajronline.org/content/197/2/W353.abstract?rss=1

The purpose of this article is to present the cases of four women who underwent percutaneous breast biopsy with deployment of a titanium metallic marker embedded in a bioresorbable collagen plug. Routine follow-up mammography after benign pathologic results were obtained revealed new fine microcalcifications at the biopsy sites, requiring repeat biopsy. Pathologic examination confirmed the presence of microcalcifications associated with an acidophilic foreign material.

Flat epithelial atypia of the breast: pathological-radiological correlation

Flat epithelial atypia of the breast: pathological-radiological correlation. AJR, Sept 2011, vol. 197(3), p. 740-746.

Solorzano, S., et al.

http://www.ajronline.org/content/197/3/740.abstract?rss=1

This study was undertaken to determine the prevalence of flat epithelial atypia at ultrasound-guided and stereotactically guided needle biopsies, to describe the mammographic and sonographic features of flat epithelial atypia, and to determine the significance of lesions diagnosed as flat epithelial atypia at imaging-guided needle biopsies.

Supplemental use of optical diffusion breast imaging for differentiation between benign and malignant breast lesions

Supplemental use of optical diffusion breast imaging for differentiation between benign and malignant breast lesions. AJR, Sept 2011, vol. 197(3), p. 732-739.

Moon, JH, et al.

http://www.ajronline.org/content/197/3/732.abstract?rss=1

The objective of this study was to prospectively evaluate the diagnostic accuracy of optical diffusion breast imaging in patients who underwent conventional ultrasound followed by surgery or biopsy.

Image guided preoperative hookwire localization of nonpalpable extramammory lesions

Image guided preoperative hookwire localization of nonpalpable extramammory lesions. AJR, Sept 2011, vol. 197(3), p. W525-W527

Kelan, KJ, et al.

http://www.ajronline.org/content/197/3/W525.abstract?rss=1

Imaging-guided hookwire localization of nonpalpable lesions in the breast is frequently performed preoperatively. Outside the breast, this procedure is useful for planning resection of lesions in anatomic regions without intrinsic landmarks. The purpose of this study was to review an experience with hookwire localization of nonpalpable extramammary lesions.

Management of uncommon chemotherapy-induced emergencies

Management of uncommon chemotherapy-induced emergencies. The Lancet Oncology, Aug 2011, vol. 12(8), p.806-814.

Morgan, C., et al.

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(10)70208-4/abstract?rss=yes

Chemotherapy can induce various clinical emergencies. Prompt recognition and management of these adverse events are important for avoiding further morbidity and mortality.

Mastectomy and reconstruction in stage IV breast cancer

Mastectomy and reconstruction in stage IV breast cancer: A survery of UK breast and plastic surgeons. The Breast, Aug 2011, vol. 20(4), p.373-79.

Durrant, CAT, et al.

http://www.thebreastonline.com/article/PIIS0960977611000452/abstract?rss=yes

The number of women with stage IV disease who have breast reconstruction is small. The primary aim of this study was to examine opinions as to the appropriateness of breast reconstruction in this group.

Interest in cavity shaving in breast conservation treatment does not depend on lumpectomy technique

Interest in cavity shaving in breast conservation treatment does not depend on lumpectomy technique. The Breast, Aug 2011, vol. 20(4), p.358-64.

Feron, JG., et al.

http://www.thebreastonline.com/article/PIIS0960977611000300/abstract?rss=yes

In breast conserving surgery (BCS), the usefulness to perform systematic cavity shaving is actively debated. Some investigators argued that systematic cavity shaving could avoid surgical re-excision and make diagnosis of unexpected multifocality. Others argued that usefulness of cavity shaving depends on volumes of resection.

Optimal adjuvant therapy for very young breast cancer patients

Optimal adjuvant therapy for very young brest cancer patients. The Breast, Aug 2011, vol. 20(4), p.297-302.

Francis, PA.

http://www.thebreastonline.com/article/PIIS0960977611001032/abstract?rss=yes

Approximately one in forty women diagnosed with early breast cancer is very young (<35 years) and this age group has a worse prognosis. The inferior prognosis in very young women appears to have two aspects. Very young women present more frequently with tumors with adverse histo-pathologic features. However, even when the histo-pathologic features appear favorable (ie. endocrine responsive tumors), analyses suggest that very young women with hormone receptor positive tumors are a sub-group at particular risk for adverse outcomes, compared to older premenopausal women with similar tumors

How not to neglect the care of the elderly breast cancer patients

How not to neglect the care of the elderly breast cancer patient. The Breast, Aug 2011, vol. 20(4), p.293-96.

Tahir, M., et al.

http://www.thebreastonline.com/article/PIIS0960977611000907/abstract?rss=yes

Breast cancer is one of the leading causes of cancer mortality in women. Its incidence increases with increasing age; those over 70 years constitute more than one-third of the current breast cancer population. Despite significant advances in the field of breast cancer treatment, elderly patients have seen neither a meaningful improvement in treatment strategies, nor a decline in breast cancer-specific mortality.

Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable HER2 positive breast cancer

Four year follow-up of trastuzumab plus adjuvant chemotherpy for operable HER2 positive breast cancer: Joint analysis of NNCTG N9831 and NSABP B-31. J Clin Oncol published online before print July 18, 2011

Wan, Y. (summary)

http://www.nelm.nhs.uk/en/NeLM-Area/News/2011---July/19/Four-year-follow-up-of-trastuzumab-plus-adjuvant-chemotherapy-for-operable-HER2-positive-breast-cancer-Joint-analysis-of-NCCTG-N9831-and-NSABP-B-31/

Four large trials evaluating adjuvant trastuzumab for HER2-positive breast cancer demonstrated significant improvements in disease-free survival (DFS; 36% to 52% reduction in DFS events) and overall survival (OS; 33% to 37% reduction in deaths). These data has led adjuvant trastuzumab becoming the foundation of care for HER2-positive early breast cancer.

High-dose chemotherapy with stem-cell support gives no apparent survival benefit in breast cancer

High-dose chemotherapy with stem-cell support gives no apparent survival benefit in breast cancer. J Clin Oncol, published early online 18 July 2011

Glare, J. (summary)

http://www.nelm.nhs.uk/en/NeLM-Area/News/2011---July/20/High-dose-chemotherapy-with-stem-cell-support-gives-no-apparent-survival-benefit-in-breast-cancer/

Two meta-analyses published early online by the Journal of Clinical Oncology examine the evidence on high-dose chemotherapy with stem-cell support in high-risk primary and in metastatic breast cancer: both found that while the technique produced small increases in relapse-free survival, it did not significantly prolong overall survival.

Triptorelin reduces risk of ovarian failure due to chemotherapy for breast cancer

Triptorelin reduces risk of ovarian failure due to chemotherapy for breast cancer. JAMA 2011; 306: 269-76

Glare, J. (summary)

http://www.nelm.nhs.uk/en/NeLM-Area/News/2011---July/20/Triptorelin-reduces-risk-of-ovarian-failure-due-to-chemotherapy-for-breast-cancer/

Breast cancer in younger women is less common, about 12% aged under 45 years, but they are at increased risk of an adverse outcome and therefore most will receive intensive systemic chemotherapy. This may cause early ovarian failure leading to premature menopause: it is estimated that each month of chemotherapy translates into 1.5 years of lost reproductive life. There are no proven standard strategies for preventing this toxicity, however experimental work and pilot studies suggest that suppressing ovarian function with a gonadotropin-releasing hormone (GnRH) analogue might be helpful. This trial examined the hypothesis.

Role of mammography in the triple assessment of single-quadrant breast symptoms

Role of mammography in the triple assessment of single-quadrant breast symptoms.

British journal of surgery, vol 98(7), p.951-5.

Donnelly, J., et al.

http://onlinelibrary.wiley.com/doi/10.1002/bjs.7490/full

Most women over the age of 35 years referred to a breast clinic have single-quadrant symptoms and undergo mammography (MMG) as part of the triple assessment of these. A proportion of these women has no abnormality clinically or on ultrasonography (P1 U1). The aim of this study was to assess the additional contribution of MMG in diagnosing cancer in patients with P1 U1 findings and to consider whether it is safe to be more selective when requesting MMG.

Library stock: Association of Breast Surgery Yearbook

2011 Association of Breast Surgery Yearbook available for loan.
Containing articles, reports, audits, education and training features, plus breast cancer screening and prognosis.

2011 RCN Cancer and Breast Care Conference

RCN Cancer and Breast Care Conference 2011
Location: Thistle Marble Arch, Bryantson Street, London, W1H 7EH
Date: 25 November 2011 to 25 November 2011
This event welcomes nurses, APs and HCAs with an interest in cancer and breast care.

New England Journal of Medicine: 364 June 2011

Exemestane for Breast-Cancer Prevention in Postmenopausal Women

Paul E. Goss, et al

N Engl J Med 2011; 364:2381-2391
June 23, 2011

Access the abstract using your Athens username and password

The Breast Journal: Vol 17 Iss 3 May/June 2011

The Utility of Breast MRI as a Problem-Solving Tool
Edwin J. et al

Abstract

pages 273–280, May/June 2011
Article first published online: 8 APR 2011

British Journal of Surgery Vol 98 Issue 7 July 2011

Role of mammography in the triple assessment of single-quadrant breast symptoms

Donnelly, J. et al
Volume 98, Issue 7
pages 951–955,
July 2011

Article first published online: 20 Apr 2011

Access these articles using your Athens username and password under 'Institutional login'

Lancet Oncology Vol 12; No 5 May 2011

Preventive therapy for breast cancer: a consensus statement

12 May 2011
pp. 496-503
Cuzick, J. et al

Please contact the Library staff if you require full text access to this article.

Journal of Medical Screening Vol 18 No 1 May 2011

False-positive mammographic screening: factors influencing re-attendance over a decade of screening

02 May 2011,

Fitzpatrick, P. et al

'A mastectomy for something that wasn't even truly invasive cancer.' Women's understandings of having a mastectomy for screen-detected DCIS: a qualitative study
02 May 2011,

Prinjha, S., et al

Abstracts only

The Kings Fund: Improving Cancer Survival Report

Existing differences in cancer survival rates are considered between countries and discusses the reasons for these variations including: stage at diagnosis and diagnostic delay; treatment factors; patient factors; and tumour biology and physiological/biological factors.

The full text of the report is available at:
http://www.kingsfund.org.uk/publications/cancer_survival.html

Association of Breast Surgery: Screening Audit 2009-2010

Significant survival improvement shown in the NHS Breast Screening Programme audit for 2009-March 2010.

Click here for the full text link

Temporary suspension of Breast Surgery Bulletin

Due to staff changes, updates to the Breast Surgery blog have temporarily ceased. It is hoped that this service will resume during May 2011.

AJR Vol 196 Iss 3 March 2011

N.B. Please contact the Library staff if you require full text access to any of the following articles.

Accuracy of Diagnostic Mammography and Breast Ultrasound During Pregnancy and Lactation.
Jessica Robbins et al.

Management of Ultrasonographically Detected Benign Papillomas of the Breast at Core Needle Biopsy.
Jung Min Chang et al.

Interobserver Variability of Ultrasound Elastography: How It Affects the Diagnosis of Breast Lesions.
Jung Hyun Yoon et al.

Localized Detection and Classification of Abnormalities on FFDM and Tomosynthesis Examinations Rated Under an FROC Paradigm.
David Gur et al.

British Journal of Surgery Vol 98 Iss 4 April 2011

Access these articles using your Athens username and password under 'Institutional login'

Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma
p527-535
K. L. Snook et al.

Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma (Commentary)
p536
R. I. Cutress

Effect of abnormal screening mammogram on quality of life
p537-542
A. F. W. van der Steeg et al.

Effect of abnormal screening mammogram on quality of life (Commentary)
p542-543
M. Baum

Annals of Surgery Vol 253 Iss 3 March 2011

Access this article using your Athens username and password

Classification of Ipsilateral Breast Tumor Recurrences After Breast Conservation Therapy Can Predict Patient Prognosis and Facilitate Treatment Planning.
pg. 572-579
Yi, Min MD et al.

Plastic and Reconstructive Surgery Vol 127 Iss 3 March 2011

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Acellular Dermal Matrix for the Treatment and Prevention of Implant-Associated Breast Deformities.
pg. 1047-1058
Spear, Scott L. M.D et al.

A Reliable Method for the Preoperative Estimation of Tissue to Be Removed during Reduction Mammaplasty.
pg. 1059-1064
Kocak, Ergun M.D et al.

Effect of Intraoperative Saline Fill Volume on Perioperative Outcomes in Tissue Expander Breast Reconstruction.
pg. 1065-1072
Crosby, Melissa A. M.D et al.

Preventing Venous Congestion of the Nipple-Areola Complex: An Anatomical Guide to Preserving Essential Venous Drainage Networks.
pg. 1073-1079
le Roux, Cara Michelle B.Biomed.Sc., B.Sc.(Hons.) et al.

Tissue Oximetry Monitoring in Microsurgical Breast Reconstruction Decreases Flap Loss and Improves Rate of Flap Salvage.
pg. 1080-1085
Lin, Samuel J. M.D et al.

Morbidity of Microsurgical Breast Reconstruction in Patients with Comorbid Conditions.
pg. 1086-1092
Seidenstuecker, Katrin M.D et al.

Stacked Deep Inferior Epigastric Perforator Flap Breast Reconstruction: A Review of 110 Flaps in 55 Cases over 3 Years.
pg. 1093-1099
DellaCroce, Frank J. M.D et al.

Optimal Timing of Delayed Free Lower Abdominal Flap Breast Reconstruction after Postmastectomy Radiation Therapy.
pg. 1100-1106
Baumann, Donald P. M.D et al.

Contouring the Inferior Pole of the Breast in Vertical Mammaplasty: Suction-Assisted Lipectomy versus Direct Defatting.
pg. 1314-1322
Akyurek, Mustafa M.D., Ph.D.

Sentinel Lymph Node Detection in a Patient with Subungual Melanoma after Transaxillary Breast Augmentation.
pg. 65e-66e
Graf, Ruth Maria M.D., Ph.D et al.

Plastic and Reconstructive Surgery Vol 127 Iss 2 February 2011

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Introducing the Septocutaneous Gluteal Artery Perforator Flap: A Simplified Approach to Microsurgical Breast Reconstruction.
pg. 489-495
Tuinder, Stefania M.D et al.

Does Previous Chest Wall Irradiation Increase Vascular Complications in Free Autologous Breast Reconstruction?
pg. 496-504
Fosnot, Joshua M.D et al.

A Combined Anatomical and Clinical Study for Quantitative Analysis of the Microcirculation in the Classic Perfusion Zones of the Deep Inferior Epigastric Artery Perforator Flap
pg. 505-513
Rahmanian-Schwarz, Afshin M.D et al.

An 8-Year Experience of Direct-to-Implant Immediate Breast Reconstruction Using Human Acellular Dermal Matrix (AlloDerm).
pg. 514-524
Salzberg, C. Andrew M.D et al.

Occult Carcinoma in 866 Reduction Mammaplasties: Preserving the Choice of Lumpectomy.
pg. 525-530
Slezak, Sheri M.D and Bluebond-Langner, Rachel M.D.

Temporary Banking of the Nipple-Areola Complex in 97 Skin-Sparing Mastectomies.
pg. 531-539
Ahmed, A. Kalam J. M.D et al.

Breast Journal Vol 17 Iss 1 Jan - Feb 2011

Sentinel lymph node biopsy in breast cancer: an analysis of the maximum number of nodes requiring excision.
Gill J et al.
p3-8
Abstract only

Improvement in dcis detection rates by mri over time in a high-risk breast screening study.
Warner E et al.
p9-17
Abstract only

Breast reconstruction in women under 30: a 10-year experience.
Ellsworth WA et al.
p18-23
Abstract only

Outcome of small invasive breast cancer with no axillary lymph node involvement.
Sánchez-Muñoz A et al.
p32-8
Abstract only

The prognosis of tumors with only microscopic skin involvement without clinical t4b signs is significantly better than t4b tumors in breast carcinoma.
Duraker N et al.
p47-55
Abstract only

Sentinel lymph node biopsy after neo-adjuvant chemotherapy in breast cancer.
Stell VH et al
p71-4
Abstract only

Age <40> is an independent prognostic factor predicting inferior overall survival in patients treated with breast conservative therapy
Kim K et al.
p75-8
Abstract only


N.B. Articles for which there is no abstract are not included here.

Journal of Medical Screening Vol 17 Iss 4 2010

Women's preferences for the delivery of the National Health Service Breast Screening Programme: a cross-sectional survey (Abstract only)
Louise Linsell et al.
p176—180

NEJM Vol 364 Iss 5 Feb 3 2011

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Effect of Occult Metastases on Survival in Node-Negative Breast Cancer
Donald L Weaver et al.
p. 412

NEJM Vol 364 Iss 3 Jan 20 2011

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Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer
Joyce O'shaughnessy et al.
p. 205

More on Screening Mammography
John P Burke et al.
p. 281

AJR Vol 196 Iss 2 February 2011

N.B. Please contact the Library staff if you require full text access to any of the following articles.

Preoperative Sentinel Node Identification With Ultrasound Using Microbubbles in Patients With Breast Cancer.
Ali R. Sever et al.

Breast Imaging and Intervention in the Overweight and Obese Patient.
Stamatia Destounis et al.

Detection and Classification of Calcifications on Digital Breast Tomosynthesis and 2D Digital Mammography: A Comparison.
M. Lee Spangler et al.

British Journal of Surgery Vol 98 Iss 3 March 2011

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Assessing the clinical effectiveness of breast reconstruction through patient-reported outcome measures
Z. E. Winters and H. J. Thomson
p323-325

Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy
B. J. van Wely, S. et al.
p326-333

Annals of Surgery Vol 253 Iss 2 February 2011

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Perioperative Reductions in Circulating Lymphocyte Levels Predict Wound Complications After Excisional Breast Cancer Surgery.
pg. 360-364
Hogan, Brian V. MBBCh et al.

AJR Volume 196 Iss 1 January 2011

N.B. Please contact the Library staff if you require full text access to any of the following articles.

Predictive Value for Malignancy of Suspicious Breast Masses of BI-RADS Categories 4 and 5 Using Ultrasound Elastography and MR Diffusion-Weighted Imaging.
Hiroko Satake et al.

Contribution of Diffusion-Weighted Imaging to Dynamic Contrast-Enhanced MRI in the Characterization of Breast Tumors.
Sibel Kul et al.

Background Parenchymal Enhancement on Baseline Screening Breast MRI: Impact on Biopsy Rate and Short-Interval Follow-Up.
Niamh M. Hambly et al.

Sonographic Confirmation of a Mammographically Detected Breast Lesion.
Richard L. Ellis

High Cancer Yield and Positive Predictive Value: Outcomes at a Center Routinely Using Preoperative Breast MRI for Staging.
Robert L. Gutierrez et al.

British Journal of Surgery Vol 98 Iss 2 February 2011

Evidence-based review of enhancing postoperative recovery after breast surgery (pages 181–196)
R. Arsalani-Zadeh et al.
p181-196
(Access this article using your Athens username/password under 'Institutional login')

Plastic and Reconstructive Surgery Vol 127 Iss 1 January 2011

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Is Oncologic Safety Compatible with a Predictably Viable Mastectomy Skin Flap?
pg. 27-33
Larson, David L. M.D et al.

Internal Mammary Intercostal Perforators instead of the True Internal Mammary Vessels as the Recipient Vessels for Breast Reconstruction.
pg. 34-40
Follmar, Keith E. M.D et al.

Chronic Postoperative Breast Pain: Danger Zones for Nerve Injuries.
pg. 41-46
Ducic, Ivica M.D et al.