Showing posts with label gene signature. Show all posts
Showing posts with label gene signature. Show all posts

Thursday, 28 February 2019

EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer



 by Steven A. Buechler, Yesim Gökmen–Polar, Sunil S. Badve  

The Breast: February 2019, Volume 43, Pages 74-80

Highlights:
•EarlyR gene signature uses expression of 5 genes to stratify ER + breast cancer patients by prognosis.
•EarlyR has been previously validated in 2 randomized clinical trials.
•The current study documents the ability of EarlyR to predict pathological complete response (pCR).
•EarlyR predicts survival in NACT-treated ER + patients.
•EarlyR is both a prognostic assay and a predictive assay.