Thursday 16 May 2013

Arm lymphoedema after breast cancer

Arm lymphoedema after breast cancer. The lancet oncology, May 2013, Vol. 14(6), p.442-43

Mortimer, P.

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70097-4/fulltext?_eventId=login&rss=yes

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Breast-cancer-related lymphoedema is a substantial problem in women after they have undergone breast cancer treatment. Despite the introduction of breast-conserving surgery and minimal lymphatic intervention (eg, sentinel-lymph-node biopsy [SLNB]), incidence rates remain disappointingly high. In The Lancet Oncology, Tracey DiSipio and colleagues report the findings of their systematic review and meta-analysis in which they shown that roughly one in five women with breast cancer will develop arm lymphoedema. The incidence was four times higher in women undergoing axillary lymph-node dissection compared with those who received sentinel-lymph-node biopsy.


Predictors of axillary lymph node metastases in early breast cancer

Predictors of axillary lymph node metastases in early breast cancer and their applicability in clinical practice. The breast, June 2013, Vol. 22(3), p.357-61.

Yoshihara, E., et al.

http://www.thebreastonline.com/article/PIIS0960977612001890/abstract?rss=yes

Lymph node involvement is the most important prognostic factor in breast cancer. It is a multifactorial event determined by patient and tumour characteristics. The purpose of this study was to determine clinical and pathological factors predictive for axillary lymph node metastasis (ALNM) in patients with early breast cancer and to build a model to portend lymph node involvement.

Detection of local recurrence following breast-conserving treatment in young women with early breast cancer

Detection of local recurrence following breast-conserving treatment in young women with early breast cancer: Optimization of long-term follow-up strategies. The breast, June 2013, Vol. 22(3), p.351-56

van der Sangen, M.J.C., et al.

http://www.thebreastonline.com/article/PIIS0960977612001865/abstract?rss=yes

The detection of a local recurrence (LR) in young women with breast cancer after breast-conserving treatment (BCT) was investigated to compare the impact of different long-term follow-up strategies.

Association between common risk factors and molecular subtypes in breast cancer patients

Association between common risk factors and molecular subtypes in breast cancer patients. The breast, June 2013, Vol. 22(3), p.344-50.

Turkoz, F.P., et al.

http://www.thebreastonline.com/article/PIIS0960977612001737/abstract?rss=yes

Breast cancer is the most commonly diagnosed cancer in women worldwide and characterized its by molecular and clinical heterogeneity. Gene expression profiling studies have classified breast cancers into five subtypes: luminal A, luminal B, HER-2 overexpressing, basal-like, and normal breast-like. Although clinical differences between subtypes have been well described in the literature, etiologic heterogeneity have not been fully studied. The aim of this study was to assess the associations between several hormonal and nonhormonal risk factors and molecular subtypes of breast cancer.

Acupuncture relieves menopausal discomfort in breast cancer patients

Acupuncture relieves menopausal discomfort in breast cancer patients: A prospective, double blinded, randomized study. The breast, June 2013, Vol. 22(3), p.320-23

Bokmand, S. and Flyger, H.

http://www.thebreastonline.com/article/PIIS096097761200166X/abstract?rss=yes

his study evaluates the effect of acupuncture on hot flashes and disturbed night sleep in patients treated for breast cancer. The effect of acupuncture was tested against a sham-acupuncture group and a no-treatment control group. Plasma estradiol was measured to rule out this as cause of effect. Side effects of the treatment were registered.


Pathological response and survival after neoadjuvant therapy for breast cancer

Pathological response and survival after neoadjuvant therapy for breast cancer: A 30-year study. The breast, June 2013, Vol. 22(3), p.301-08

Guiu, S., et al.

http://www.thebreastonline.com/article/PIIS0960977612001634/abstract?rss=yes

HER2-positive and triple-negative breast cancer (TNBC) still have a poor prognosis. Pathological complete response (pCR) is usually considered a surrogate marker for outcome. The aim of this study was to reconsider these parameters on a large population after a long follow-up. 

Factors influencing postoperative length of hospital stay after breast cancer surgery

Factors influencing postoperative length of hospital stay after breast cancer surgery. The breast, June 2013, Vol. 22(3), p.289-294

Marla, S., et al.

http://www.thebreastonline.com/article/PIIS0960977612001609/abstract?rss=yes

As part of a feasibility study to restructure the breast cancer services in Glasgow, factors influencing ‘postoperative length of stay’ and bed utilisation in patients undergoing surgery for breast cancer were examined.

Differences in sleep disturbance, fatigue and energy levels between women with and without breast pain prior to breast cancer surgery

Differences in sleep disturbance, fatigue and energy levels between women with and without breast pain prior to breast cancer surgery. The breast, June 2013, Vol. 22(3), p.273-76

Van Onselen, C., et al.

http://www.thebreastonline.com/article/PIIS0960977612001531/abstract?rss=yes

The purpose of this study was to evaluate for differences in occurrence and severity ratings of sleep disturbance, fatigue, and decreased energy in women who reported breast pain prior to surgery for breast cancer. Of the 390 women who completed self-report measures for each symptom, 28.2% reported pain in their breast prior to surgery. 

International guidelines for management of metastatic breast cancer

International guidelines for management of metastatic breast cancer from the European School of Oncology - MBC Task Force: Surveillance, staging and evaluation of patients with early-stage and metastatic breast cancer. The breast, June 2013, Vol. 22(3), p.203-10

Lin, N.U, et al.

http://www.thebreastonline.com/article/S0960-9776(13)00062-3/abstract

In clinical practice, the surveillance and follow-up of patients with breast cancer (BC) is quite variable. At the 7th European Breast Cancer Conference, the ESO-MBC Task Force convened a series of lectures, followed by open debate, on the use of physical examination, imaging, and laboratory tests in patients with early-stage BC, and for restaging evaluations and follow-up among patients with MBC.




Leser-Trelat sign and breast cancer

Leser-Trelat sign and breast cancer. The lancet, May 2013, Vol. 381(9878), p.1653

Al Ghazal, P., et al.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61257-4/fulltext?rss=yes

A 71-year-old, obese woman presented to our clinic with multiple seborrheic keratoses over her entire body. She reported the rapid appearance of the tumours several weeks before an initial diagnosis of breast cancer. 

Thursday 2 May 2013

Persistent pain and sensory disturbances after treatment for breast cancer

Persistent pain and sensory disturbances after treatment for breast cancer: six-year nationwide follow-up study. BMJ 2013; 346.

Mejdahl, M.K., et al.

http://www.bmj.com/highwire/filestream/640586/field_highwire_article_pdf/0/bmj.f1865.full.pdf

Objective: Toexamine thedevelopment of persistent pain after treatment for breast cancer and to examine risk factors associated with continuing pain.Design: Repeated cross sectional study in a previously examined

nationwide cohort.All eligible women who underwent surgery for primary breast cancer in Denmark in 2005 and 2006 and were examined in 2008 were surveyed again with the same questionnaire.

Breast reconstruction modality outcome study

Breast reconstruction modality outcome study: A comparison of expander/implants and free flaps in select patients. Plastic and reconstructive surgery, May 2013, Vol. 131(5), p.928-34.

Fischer, J.P., et al.

http://journals.lww.com/plasreconsurg/Fulltext/2013/05000/Breast_Reconstruction_Modality_Outcome_Study___A.2.aspx

Choosing a breast reconstructive modality after mastectomy is a critical step involving complex decisions. The authors provide outcomes data comparing two common reconstructive modalities to assist patients and surgeons in preoperative counselling and discussions.

Repairing the high-riding nipple with reciprocal transposition flaps

Repairing the high-riding nipple with reciprocal transposition flaps. Plastic and reconstructive surgery, April 2013, Vol. 131(4), p.687-89.

Spear, S.L., et al.

http://journals.lww.com/plasreconsurg/Abstract/2013/04000/Repairing_the_High_Riding_Nipple_with_Reciprocal.5.aspx

The high-riding nipple-areola complex is a clinical problem that can be encountered following cosmetic and reconstructive breast surgery. Because of the desire to avoid scars on the superior aspect of the breast and the limited availability of superior breast skin, it can be technically challenging to place the nipple-areola complex in a lower position. 

Double venous system drainage in deep inferior epigastric perforator flap breast reconstruction

Double venous system drainage in deep inferior epigastric perforator flap breast reconstruction: a single-surgeon experience. Plastic and reconstructive surgery, April 2013, Vol. 131(4), p.671-76

Boutros, S.G.

http://journals.lww.com/plasreconsurg/Abstract/2013/04000/Double_Venous_System_Drainage_in_Deep_Inferior.1.aspx

Breast reconstruction with the deep inferior epigastric perforator (DIEP) flap has many advantages. The main drawback is the technical difficulty and risk of failure. Many flap failures are the result of venous insufficiency. The author explored the routine use of double venous system anastomosis in DIEP flap breast reconstruction.

Incidence of unilateral arm lymphoedema after breast cancer

Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis.  The lancet oncology, May 2013, Vol. 14(6), p.500-15.

DiSippio, T., et al.

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70076-7/abstract?rss=yes

The body of evidence related to breast-cancer-related lymphoedema incidence and risk factors has substantially grown and improved in quality over the past decade. We assessed the incidence of unilateral arm lymphoedema after breast cancer and explored the evidence available for lymphoedema risk factors.