Thursday 7 July 2016

Ribociclib plus letrozole in early breast cancer: A presurgical, window-of-opportunity study

Ribociclib plus letrozole inearly breast cancer: A presurgical, window-of-opportunity study

The Breast August 2016 Volume 28, Pages 191–198

Curigliano G et al

Cyclin D–cyclin-dependent kinase (CDK) 4/6–inhibitor of CDK4/6–retinoblastoma (Rb) pathway hyperactivation is associated with hormone receptor-positive (HR+) breast cancer (BC). This study assessed the biological activity of ribociclib (LEE011; CDK4/6 inhibitor) plus letrozole compared with single-agent letrozole in the presurgical setting.

Positive margins prediction in breast cancer conservative surgery: Assessment of a preoperative web-based nomogram

Positive margins prediction in breast cancer conservative surgery: Assessment of a preoperative web-based nomogram

The Breast August 2016 Volume 28, Pages 167–173

Alves-Ribeiro L et al

Margin status of the surgical specimen has been shown to be a prognostic and risk factor for local recurrence in breast cancer surgery. It has been studied as a topic of intervention to diminish reoperation rates and reduce the probability of local recurrence in breast conservative surgery (BCS).This study aims to validate the Dutch Breast Conservation nomogram, created by Pleijhus et al., which predicts preoperative probability of positive margins in BCS.Patients with diagnosis of breast cancer stages cT1-2, who underwent BCS at the Breast Center of São João University Hospital (BC-CHSJ) in 2013–2014, were included.

Five-year results of a prospective clinical trial investigating accelerated partial breast irradiation using 3D conformal radiotherapy after lumpectomy for early stage breast cancer

Five-year results of aprospective clinical trial investigating accelerated partial breast irradiation using 3D conformal radiotherapy after lumpectomy for early stage breast cancer

The Breast August 2016 Volume 28, Pages 178–183

Horst KC et al

Accelerated partial breast irradiation (APBI) is emerging as an alternative to whole-breast irradiation. This study presents the results of a prospective trial evaluating 3-dimensional conformal radiotherapy (3D-CRT) to deliver APBI for early-stage breast cancer.

Decision making, psychological wellbeing and psychosocial outcomes for high risk women who choose to undergo bilateral prophylactic mastectomy – A review of the literature

Decision making, psychologicalwellbeing and psychosocial outcomes for high risk women who choose to undergobilateral prophylactic mastectomy – A review of the literature

The Breast August 2016 Volume 28, Pages 130–135

Glassey R, Ives A, Saunders C, Musiello T

A bilateral prophylactic, or preventative, mastectomy (BPM) for women at high risk of developing breast cancer (BC) can reduce their risk of developing the disease by up to 90% (relative risk reduction). An increasing number of women, including young women, are taking up this option. However, there is a dearth of information for younger women (under 40 years) choosing preventative mastectomy. In fact, no studies to date have specifically focused on younger women's experiences of a BPM and investigated their informational needs.

Chemotherapy port related lymphedema after axillary lymph node dissection

Chemotherapy port related lymphedema after axillary lymph node dissection
The Breast August 2016 Volume 28, Pages 145–147

Turfe Z et al

The Mascagni lymphatic pathway comprises superficial channels along the clavicle that drain upper extremity lymph. A 65 year-old woman with recurrent left breast cancer presented with a non-functioning chemotherapy port in the right deltopectoral groove. She had undergone right mastectomy with axillary lymph node dissection (ALND). After port removal and wound closure she developed right upper extremity lymphedema. Patients who have undergone ALND may depend solely on this pathway for upper extremity lymphatic drainage.