Tuesday, 8 November 2011

Calpastatin is associated with lymphovascular invasion in breast cancer

Calpastatin is associated with lympovascular invasion in breast cancer. The Breast, Oct 2011, Vol. 20(5), p. 413-418

Storr, SJ, et al.

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to examine genes and proteins involved in lymphovascular invasion (LVI) to understand the mechanisms of this key disease process. The data supports the hypothesis that calpastatin may play a role in regulating the initial metastatic dissemination of breast cancer.