by Sophie Frank, Matthieu Carton, Coraline Dubot, Mario
Campone, Barbara Pistilli, Florence Dalenc, Audrey Mailliez, Christelle Levy,
Véronique D’Hondt, Marc Debled, Thomas Vermeulin, Bruno Coudert, Christophe
Perrin, Anthony Gonçalves, Lionel Uwer, Jean-Marc Ferrero, Jean-Christophe
Eymard, Thierry Petit, Marie-Ange Mouret-Reynier, Anne Patsouris, Tahar
Guesmia, Thomas Bachelot, Mathieu Robain, Paul Cottu
The Breast: VOLUME
52, P50-57, AUGUST 01, 2020
Highlights
•Young age is a poor prognosis factor in early stage breast
cancer.
•Young age is associated with an aggressive presentation in
metastatic breast cancer.
•Young age had no impact on overall survivall in metastatic
breast cancer.
•Oppositely, older women (>60y) had a stightly poorer
prognosis at the metastatic stage.
Abstract
Background
Young age is a poor prognostic factor in early stage breast
cancer (BC) but its value is less established in metastatic BC (MBC). We
evaluated the impact of age at MBC diagnosis on overall survival (OS) across
three age groups (<40 40="" 60="" and="" nbsp="" to=""> 60 years(y)).
Methods
ESME MBC database is a national cohort, collecting
retrospective data from 18 participating French cancer centers between January
01, 2008 and December 31, 2014.
Results
Among 14 403 women included, 1077 (7.5%), 6436 (44.7%)
and 6890 (47.8%) pts were <40 40="" and="" nbsp=""> 60 y
respectively. Pts <40 15.3="" age="" aggressive="" frequent="" groups:="" had="" her2="" in="" more="" other="" presentations="" significantly="" than="" vs="">60y) and triple
negative subtypes (27.4 vs 14.6% in >60y), and more frequent visceral
involvement (36.3 vs 29.8% in >60y). At a median follow-up of 48 months,
median OS differed across age groups: 38.8, 38.4 and 35.6 months for pts
<40 40="" and="" nbsp=""> 60y, respectively (p < 0.0001).
Compared to pts <40y 40="" 74.9="" 81.9="" 86.6="" 95="" a="" all="" although="" and="" anti-her2="" as="" better="" causes="" clinical="" death="" diseases.="" explanation="" first-line="" for="" greater="" had="" her2="" higher="" ic="" in="" included="" is="" limited="" luminal="" nbsp="" of="" older="" os="" possible="" pts="" risk="" significant="" statistically="" therapies="" there="" treatments:="" trend="" use="" value="" was="" with="" y=""> 60y, respectively
(p < 0.0001).
Conclusion
Although young age seems associated with more aggressive
presentations at diagnosis of MBC, it has no deleterious effect on OS in this
large series.
