Sexuality, a topic that surgeons should discuss with women before risk-reducing mastectomy and breast reconstruction

Sexuality, a topic that surgeons should discuss with women before risk-reducing mastectomy and breast reconstruction

 by Rieky E.G. Dikmans, Tim C. van de Grift, Mark-Bram Bouman, Andrea L. Pusic, Margriet G. Mullender

The Breast: February 2019, Volume 43, Pages 120-122

While sexual health is an important aspect of quality of life, sexual issues usually go unaddressed during patient-provider communication. Breast cancer treatments and specifically breast surgery impact women's sexual well-being. However, women do not receive adequate information on this subject. Women who underwent prophylactic mastectomy and breast reconstruction invariably reported that they had underestimated the impact of mastectomy and reconstruction on their sexuality, and expressed a need for information and creating realistic expectations pertaining to sexuality.

[News] New triple-negative breast cancer risk genes identified

[News] New triple-negative breast cancer risk genes identified

by Elizabeth Gourd

The Lancet Oncology : News: Volume 19, issue 9 PE445, September 01, 2018

Multigene hereditary cancer panel testing could be used to identify women with an elevated risk of triple-negative breast cancer as a result of deleterious mutations in five genes, according to a recent study.

Screening an asymptomatic person for genetic risk

Screening an asymptomatic person for genetic risk. NEJM, June 2014, 370: 2442-45 [Clinical Decisons]

Department of Bioethics and Humanities, University of Washington, Seattle

http://www.nejm.org/doi/pdf/10.1056/NEJMclde1311959

Case Study: Jim Mathis is a 45-year-old health-conscious man who has been a patient in an internal medicine–primary care practice for several years. At today’s visit, he talks about the family tree that he has sketched out and his discovery that three of his relatives had cancer — one had breast cancer, one ovarian cancer, and one prostate cancer.

Breast cancer in women at high risk

Breast cancer in women at high risk: The role of rapid genetic testing for BRCA1 and -2 mutations and the consequences for treatment strategies. The breast, Oct 2013, Vol. 22(5), p.561-68

Francken, A.B., et al.

http://www.thebreastonline.com/article/S0960-9776(13)00210-5/abstract?rss=yes

Specific clinical questions rise when patients, who are diagnosed with breast cancer, are at risk of carrying a mutation in BRCA1 and -2 gene due to a strong family history or young age at diagnosis. These questions concern topics such as 1. Timing of genetic counseling and testing, 2. Choices to be made for BRCA1 or -2 mutation carriers in local treatment, contralateral treatment, (neo)adjuvant systemic therapy, and 3. The psychological effects of rapid testing. The knowledge of the genetic status might have several advantages for the patient in treatment planning, such as the choice whether or not to undergo mastectomy and/or prophylactic contralateral mastectomy.

Perceived risk and adherence to breast cancer screening guidelines among women with a familial history of breast cancer

Perceived risk and adherence to breast cancer screening guidelines among women with a familial history of breast cancer: A review of the literature. The breast, August 2013, Vol. 22(4), p.395-404.

Walker, M.J., et al.

http://www.sciencedirect.com/science/article/pii/S0960977612002494

A small positive association has been consistently demonstrated between perceived breast cancer risk and mammography use. Evidence specific to women with familial breast cancer risk has not been previously reviewed.

Association between common risk factors and molecular subtypes in breast cancer patients

Association between common risk factors and molecular subtypes in breast cancer patients. The breast, June 2013, Vol. 22(3), p.344-50.

Turkoz, F.P., et al.

http://www.thebreastonline.com/article/PIIS0960977612001737/abstract?rss=yes

Breast cancer is the most commonly diagnosed cancer in women worldwide and characterized its by molecular and clinical heterogeneity. Gene expression profiling studies have classified breast cancers into five subtypes: luminal A, luminal B, HER-2 overexpressing, basal-like, and normal breast-like. Although clinical differences between subtypes have been well described in the literature, etiologic heterogeneity have not been fully studied. The aim of this study was to assess the associations between several hormonal and nonhormonal risk factors and molecular subtypes of breast cancer.

The Breast Journal Vol 15 Iss 1 2009

S1-S1
Breast Cancer Risk Assessment and Follow-up Management: Is There a Magic Marker to Identify High Risk Individuals?
Shahla Masood
AbstractPublished Online: 22 Sep 2009

ORIGINAL ARTICLES
S2-S10
Genetic Counseling and the Advanced Practice Oncology Nursing Role in a Hereditary Cancer Prevention Clinic: Hereditary Breast Cancer Focus (Part I)
Carrie L. Snyder, Jane F. Lynch, Henry T. Lynch
AbstractPublished Online: 22 Sep 2009
S11-S19
Genetic Counseling and the Advanced Practice Oncology Nursing Role in a Hereditary Cancer Prevention Clinic: Hereditary Breast Cancer Focus (Part II)
Henry T. Lynch, Carrie L. Snyder, Jane F. Lynch
AbstractPublished Online: 22 Sep 2009
S20-S24
Family Information Service Participation Increases the Rates of Mutation Testing Among Members of Families with BRCA1/2 Mutations
Henry T. Lynch, Carrie L. Snyder, Jane F. Lynch, Sumedha Ghate, Steven A. Narod, Gordon Gong
AbstractPublished Online: 22 Sep 2009
S25-S32
Controversies in Communication of Genetic Risk for Hereditary Breast Cancer
Amy MacKenzie, Linda Patrick-Miller, Angela R. Bradbury
AbstractPublished Online: 22 Sep 2009
S33-S38
Establishing a Family Risk Assessment Clinic for Breast Cancer
Jurgen Mulsow, James Lee, Cathriona Dempsey, Jane Rothwell, James G. Geraghty
AbstractPublished Online: 22 Sep 2009
S39-S45
Assessing Breast Cancer Risk and Providing Treatment Recommendations: Immediate Impact of an Educational Session
Sheryl G.A. Gabram, Teri Dougherty, Kathy S. Albain, Kimberly Klein, Patricia Mumby, Kit Lee, Kathy Yao, Bhuma Krishnamachari, Catheryn J. Salibay, Mary Jo Lund
AbstractPublished Online: 22 Sep 2009
S46-S55
Electronic Health Records and the Management of Women at High Risk of Hereditary Breast and Ovarian Cancer
Brian Drohan, Elissa M. Ozanne, Kevin S. Hughes
AbstractPublished Online: 22 Sep 2009
S56-S62
Influence of Race/Ethnicity on Genetic Counseling and Testing for Hereditary Breast and Ovarian Cancer
Andrea D. Forman, Michael J. Hall
AbstractPublished Online: 22 Sep 2009
S63-S71
Risk of Breast Cancer Among French-Canadian Women, Noncarriers of More Frequent BRCA1/2 Mutations and Consumption of Total Energy, Coffee, and Alcohol
Vishnee Bissonauth, Bryna Shatenstein, Eve Fafard, Christine Maugard, André Robidoux, Steven Narod, Parviz Ghadirian
AbstractPublished Online: 22 Sep 2009
S72-S75
Breast Cancer Risk Assessments Comparing Gail and CARE Models in African-American Women
Lucile L. Adams-Campbell, Kepher H. Makambi, Wayne A.I. Frederick, Melvin Gaskins, Robert L. DeWitty, Worta McCaskill-Stevens
AbstractPublished Online: 22 Sep 2009
S76-S80
Targeted Tailored Management of the Breast Cancer Patient at Risk for Harboring a Germline Mutation—Current Trends Affecting the Selection of Patients Considering Surgical Prophylaxis for Breast Cancer
Edibaldo Silva
AbstractPublished Online: 22 Sep 2009
S81-S89
Breast Reconstruction after Bilateral Prophylactic Mastectomy in Women at High Risk for Breast Cancer
Liron Eldor, Aldona Spiegel
AbstractPublished Online: 22 Sep 2009
S90-S94
Breast Ductoscopy and the Evolution of the Intra-Ductal Approach to Breast Cancer
William C. Dooley
AbstractPublished Online: 22 Sep 2009