by Mami Ogita, Kenshiro Shiraishi, Katsuyuki Karasawa, Kenji
Tokumasu, Naomi Nakajima, Tachen Chang, Jiro Kawamori, Hideomi Yamashita,
Keiichi Nakagawa
The Breast: VOLUME 52, P88-94, AUGUST
01, 2020
Highlights
•Clinical outcome of adjuvant radiotherapy for SCC of the
breast was evaluated.
•Breast SCC had poor prognosis and a high incidence of
locoregional recurrence.
•In-field recurrence following radiotherapy occurred
frequently.
•Age and lymphatic invasion were significantly associated
with increased risk of recurrence.
Abstract
Background:
Because primary squamous cell carcinoma (SCC) of the breast
is a rare disease, the standard therapy has not been established. We examined
the clinical outcomes of postoperative adjuvant radiotherapy for breast SCC.
Material and methods:
We conducted a multicenter retrospective cohort study.
Patients diagnosed with primary breast SCC who received adjuvant radiotherapy
as part of their primary definitive treatment were included. Overall survival
(OS), breast cancer-specific survival (BCSS), and recurrence-free interval
(RFi) were evaluated.
Results:
Between January 2002 and December 2017, 25 breast SCC
patients received adjuvant radiotherapy as a primary treatment were included.
Median follow-up time was 43.5 months. Three (12%), fifteen (60%) and seven
(28%) patients had clinical stage I, II and III disease, respectively. Fourteen
patients underwent breast-conserving surgery and subsequent adjuvant
radiotherapy. Eleven patients underwent mastectomy and post-mastectomy
radiotherapy. Ten patients received regional lymph node irradiation. Nine (36%)
patients had disease recurrence. The first site of recurrence was locoregional
in five, but distant metastasis arose in one. Concurrent local and distant
metastasis were seen in two. Six cases of local recurrence occurred within the
irradiated site. Seven patients died, and six of the deaths were due to breast
cancer. Five-year OS, BCSS, and Rfi were 69%, 70%, and 63%, respectively. In
multivariate analysis, age and lymphatic invasion were associated with
increased risk of recurrence.
Conclusion:
Breast SCC has a high incidence of locoregional recurrence
and poor prognosis. Age and lymphatic invasion are significant risk factors for
recurrence.
