The low uptake of breast screening in cities is a major public health issue and may be due to organisational factors: A Census-based record linkage study. The Breast, Oct 2011, Vol. 20(5), p.460-463
Kinnear, H. et al.
http://www.thebreastonline.com/article/PIIS0960977611000993/abstract?rss=yes
Cancer screening uptake is generally lower in UK cities but quantifying city-level effects from causes due to population composition that comprise cities is hampered by data limitations. The reduced uptake of screening in cities is a major public health issue; the effects are large and a large proportion of the population are affected, organisational factors appear to be the primary cause. Strategies to correct this imbalance might help reduce inequalities in health.
Tuesday, 8 November 2011
Breast cancer after hormone replacement therapy
Breast cancer after hormone replacement therapy: does prognosis differ in preimenopausal and postmenopausal women? The Breast, Oct 2011, Vol. 20(5), p.448-454
A.K. Baumgärtner, AK, et al.
Hormone replacement therapy (HRT) has been associated with higher incidence of breast cancer in postmenopausal women, but it is unclear if breast cancers developing after HRT use have different prognosis. 1053 women with hormone receptor positive non-metastasized breast cancer were analyzed in a retrospective trial, stratifying by HRT use before diagnosis. In this retrospective analysis postmenopausal HRT users seemed to have a better breast cancer prognosis. For perimenopausal HRT users however, a trend towards worse prognosis was found.
A.K. Baumgärtner, AK, et al.
Hormone replacement therapy (HRT) has been associated with higher incidence of breast cancer in postmenopausal women, but it is unclear if breast cancers developing after HRT use have different prognosis. 1053 women with hormone receptor positive non-metastasized breast cancer were analyzed in a retrospective trial, stratifying by HRT use before diagnosis. In this retrospective analysis postmenopausal HRT users seemed to have a better breast cancer prognosis. For perimenopausal HRT users however, a trend towards worse prognosis was found.
Impact of immediate breast reconstruction on breast cancer recurrence and survival
Impact of immediate breast reconstruction on breast cancer recurrence and survival. The Breast, Oct 2011, Vol. 20(5), p.437-443
Nedumpara, T., et al.
The practise of Immediate Breast Reconstruction (IBR) following mastectomy for primary breast cancer is being increasingly adopted. Here the impact of IBR on disease progression and survival was assessed following treatment for invasive breast cancer. 1697 consecutive patients received surgical treatment for operable primary breast cancer between January 1996 and December 2007. Overall, 691 (41%) received mastectomy of whom 136 (20%) underwent IBR (82 Latissimus Dorsi, 54 Subpectoral).The effect of IBR on overall survival, local and distant recurrence was analysed in all patients studied and also separately within subgroups defined by Nottingham Prognostic Index (NPI) scores.
Nedumpara, T., et al.
The practise of Immediate Breast Reconstruction (IBR) following mastectomy for primary breast cancer is being increasingly adopted. Here the impact of IBR on disease progression and survival was assessed following treatment for invasive breast cancer. 1697 consecutive patients received surgical treatment for operable primary breast cancer between January 1996 and December 2007. Overall, 691 (41%) received mastectomy of whom 136 (20%) underwent IBR (82 Latissimus Dorsi, 54 Subpectoral).The effect of IBR on overall survival, local and distant recurrence was analysed in all patients studied and also separately within subgroups defined by Nottingham Prognostic Index (NPI) scores.
Radiofrequency ablation of early breast cancer followed by delayed surgical resection
Radiofrequency ablation of early breast cancer followed by delayed surgical resection: A promising alternative to breast-conserving surgery. The Breast, Oct 2011, Vol. 20(5), p.431-436
Ohtani, S., et al.
To examine the radiofrequency ablation (RFA) reliability in early breast cancer, we performed RFA followed by delayed surgical resection on 41 patients with invasive or non-invasive breast carcinoma less than 2 cm. MRI scans were obtained before ablation and resection. Excised specimens were examined pathologically by haematoxylin-eosin and nicotinamide adenine dinucleotide-diaphorase staining. 40 patients completed 1 RFA session, which was sufficient to achieve complete tumour cell death. Overall complete ablation rate was 87.8% (36/41). There were no treatment-related complications other than that of a superficial burn in 1 case. After RFA, the tumour was no longer enhanced on MRI in 25/26 (96.2%) cases. Residual cancer, which was suspected on MRI in 1 case, was confirmed pathologically. MRI could be an applicable modality to evaluate therapeutic effect. RFA could be an alternate local treatment option to breast-conserving surgery for early breast cancer.
Ohtani, S., et al.
To examine the radiofrequency ablation (RFA) reliability in early breast cancer, we performed RFA followed by delayed surgical resection on 41 patients with invasive or non-invasive breast carcinoma less than 2 cm. MRI scans were obtained before ablation and resection. Excised specimens were examined pathologically by haematoxylin-eosin and nicotinamide adenine dinucleotide-diaphorase staining. 40 patients completed 1 RFA session, which was sufficient to achieve complete tumour cell death. Overall complete ablation rate was 87.8% (36/41). There were no treatment-related complications other than that of a superficial burn in 1 case. After RFA, the tumour was no longer enhanced on MRI in 25/26 (96.2%) cases. Residual cancer, which was suspected on MRI in 1 case, was confirmed pathologically. MRI could be an applicable modality to evaluate therapeutic effect. RFA could be an alternate local treatment option to breast-conserving surgery for early breast cancer.
Psychological impact of recall on women with BRCA mutations undergoing MRI surveillance
Psychological impact of recall on women with BRCA mutations undergoing MRI surveillance. The Breast, Oct 2011, Vol. 20(5), p.424-430
Spiegel, TN, et al.
http://www.thebreastonline.com/article/PIIS0960977611000944/abstract?rss=yes
The addition of magnetic resonance imaging (MRI) to mammography for surveillance of women with BRCA mutations significantly increases sensitivity but lowers specificity. This study aimed to examine whether MRI surveillance, and particularly recall, is associated with increased anxiety, depression, or breast cancer worry/distress. While breast MRI surveillance did not have a detrimental psychological impact on women with a BRCA1 or BRCA2 mutation, recalling these very high-risk women for further imaging after a false positive MRI scan temporarily increased their global anxiety.
Spiegel, TN, et al.
http://www.thebreastonline.com/article/PIIS0960977611000944/abstract?rss=yes
The addition of magnetic resonance imaging (MRI) to mammography for surveillance of women with BRCA mutations significantly increases sensitivity but lowers specificity. This study aimed to examine whether MRI surveillance, and particularly recall, is associated with increased anxiety, depression, or breast cancer worry/distress. While breast MRI surveillance did not have a detrimental psychological impact on women with a BRCA1 or BRCA2 mutation, recalling these very high-risk women for further imaging after a false positive MRI scan temporarily increased their global anxiety.
Calpastatin is associated with lymphovascular invasion in breast cancer
Calpastatin is associated with lympovascular invasion in breast cancer. The Breast, Oct 2011, Vol. 20(5), p. 413-418
Storr, SJ, et al.
Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to examine genes and proteins involved in lymphovascular invasion (LVI) to understand the mechanisms of this key disease process. The data supports the hypothesis that calpastatin may play a role in regulating the initial metastatic dissemination of breast cancer.
Storr, SJ, et al.
Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to examine genes and proteins involved in lymphovascular invasion (LVI) to understand the mechanisms of this key disease process. The data supports the hypothesis that calpastatin may play a role in regulating the initial metastatic dissemination of breast cancer.
Leiomyosarcoma of the breast
Leiomyosarcoma of the breast: A case report and review of the literature about therapeutic management. The Breast, Oct 2011, Vol 20(5), p.389-393
Fujita, N., et al.
A leiomyosarcoma of the breast in an 18-year-old female. No specific treatment has been established. In order to clarify appropriate therapeutic management methods, the limited data available from our and previous case reports were assessed. A leiomyosarcoma of the breast must be excised with a negative margin. If the tumor size is large and an adequate margin, greater than 3-cm margin around the excised tumor, is not achieved due to anatomical constraints, radiotherapy may be indicated.
Fujita, N., et al.
A leiomyosarcoma of the breast in an 18-year-old female. No specific treatment has been established. In order to clarify appropriate therapeutic management methods, the limited data available from our and previous case reports were assessed. A leiomyosarcoma of the breast must be excised with a negative margin. If the tumor size is large and an adequate margin, greater than 3-cm margin around the excised tumor, is not achieved due to anatomical constraints, radiotherapy may be indicated.
Thursday, 8 September 2011
Reduction mammaplasty, obesity and massive weight loss
Reduction mammaplasty, obesity and massive weight loss: Temporal relationships of satisfaction with breast contour. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 643-650.
Coriddi, M., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/Reduction_Mammaplasty,_Obesity,_and_Massive_Weight.3.aspx
Reduction mammaplasty is often performed on obese women. With the rise in bariatric procedures, secondary changes to breast contour are increasing. This study aims to investigate the temporal relationships of breast contour satisfaction with weight status.
Coriddi, M., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/Reduction_Mammaplasty,_Obesity,_and_Massive_Weight.3.aspx
Reduction mammaplasty is often performed on obese women. With the rise in bariatric procedures, secondary changes to breast contour are increasing. This study aims to investigate the temporal relationships of breast contour satisfaction with weight status.
Anaplastic large cell lymphoma and breast implants
Anaplastic large cell lymphoma and breast implants: Results from a structured expert consultation process. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 629-639.
Kim, B., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/Anaplastic_Large_Cell_Lymphoma_and_Breast.1.aspx
There are increasing concerns about a possible association between anaplastic large cell lymphoma (ALCL) and breast implants. The authors conducted a structured expert consultation process to evaluate the evidence for the association, its clinical significance, and a potential biological model based on their interpretation of the published evidence.
Kim, B., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/Anaplastic_Large_Cell_Lymphoma_and_Breast.1.aspx
There are increasing concerns about a possible association between anaplastic large cell lymphoma (ALCL) and breast implants. The authors conducted a structured expert consultation process to evaluate the evidence for the association, its clinical significance, and a potential biological model based on their interpretation of the published evidence.
A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast
A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 112e-118e.
Carty, MJ, et al.
http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/A_Patient_Death_Attributable_to_Implant_Related.5.aspx
Implant-related primary anaplastic large cell lymphoma (ALCL) of the breast is a rare clinical entity. With increasing attention being paid to this disease, most cases reported to date in the literature have demonstrated indolent clinical courses responsive to explantation, capsulectomy, chemotherapy, and/or radiotherapy. The authors describe a case of bilateral implant-related primary ALCL of the breast that proved refractory to both standard and aggressive interventions, ultimately resulting in patient death secondary to disease progression. The authors situate this case in the context of the current state of knowledge regarding implant-related primary ALCL of the breast and suggest that this entity is generally, but not universally, indolent in nature.
Carty, MJ, et al.
http://journals.lww.com/plasreconsurg/Fulltext/2011/09000/A_Patient_Death_Attributable_to_Implant_Related.5.aspx
Implant-related primary anaplastic large cell lymphoma (ALCL) of the breast is a rare clinical entity. With increasing attention being paid to this disease, most cases reported to date in the literature have demonstrated indolent clinical courses responsive to explantation, capsulectomy, chemotherapy, and/or radiotherapy. The authors describe a case of bilateral implant-related primary ALCL of the breast that proved refractory to both standard and aggressive interventions, ultimately resulting in patient death secondary to disease progression. The authors situate this case in the context of the current state of knowledge regarding implant-related primary ALCL of the breast and suggest that this entity is generally, but not universally, indolent in nature.
Anaplastic large T-cell lymphoma and breast implants
Anaplastic large T-cell lymphoma and breast implants: A review of the literature. Plastic and reconstructive surgery, Sept 2011, vol. 128(3), p. 651-661.
Jewell, M., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/09000/Anaplastic_Large_T_Cell_Lymphoma_and_Breast.4.aspx
Anecdotal reports and one case-control study suggested an association, without evidence of causation, between breast implants and anaplastic lymphoma kinase–negative anaplastic large T-cell lymphoma (ALCL), a rare non-Hodgkin's lymphoma. This review summarizes the published evidence, including case reports and epidemiologic studies.
Jewell, M., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/09000/Anaplastic_Large_T_Cell_Lymphoma_and_Breast.4.aspx
Anecdotal reports and one case-control study suggested an association, without evidence of causation, between breast implants and anaplastic lymphoma kinase–negative anaplastic large T-cell lymphoma (ALCL), a rare non-Hodgkin's lymphoma. This review summarizes the published evidence, including case reports and epidemiologic studies.
Extending the age range for breast screening in England
Extending the age range for breast screening in England: pilot study to assess the feasibility and acceptability of randomization. Journal of medical screening, June 2011, vol. 18(2), p. 96-102.
Moser, K., et al.
http://jms.rsmjournals.com/content/18/2/96.short?rss=1
To assess the feasibility and acceptability of randomizing the phased introduction of the extension of the invited age range in the National Health Service (NHS) Breast Screening Programme in England from 50–70 to 47–73 years.
Moser, K., et al.
http://jms.rsmjournals.com/content/18/2/96.short?rss=1
To assess the feasibility and acceptability of randomizing the phased introduction of the extension of the invited age range in the National Health Service (NHS) Breast Screening Programme in England from 50–70 to 47–73 years.
Screening outcomes in women over age 70 who self-refer in the NHSBSP in England
Screening outcomes in women over age 70 who self-refer in the NHSBSP in England. Journal of medical screening, June 2011, vol. 18(2), p. 291-295.
Bennett, RL, Moss, SM.
http://jms.rsmjournals.com/content/18/2/91.short?rss=1
The NHS breast screening programme (NHSBSP) in England currently invites women aged 50–70 every three years. Whilst screening is acknowledged as efficacious for women aged 50–69, several countries routinely invite women up to the age of 74. The NHSBSP in England is beginning to invite women up to the age of 73. Although the incidence of breast cancer increases with age, the possible benefits of screening older women must be balanced against shorter life expectancies and possible overdiagnosis. In England women can self-refer after reaching the invitation upper age limit.
Bennett, RL, Moss, SM.
http://jms.rsmjournals.com/content/18/2/91.short?rss=1
The NHS breast screening programme (NHSBSP) in England currently invites women aged 50–70 every three years. Whilst screening is acknowledged as efficacious for women aged 50–69, several countries routinely invite women up to the age of 74. The NHSBSP in England is beginning to invite women up to the age of 73. Although the incidence of breast cancer increases with age, the possible benefits of screening older women must be balanced against shorter life expectancies and possible overdiagnosis. In England women can self-refer after reaching the invitation upper age limit.
Breast surface radiation dose during coronary CT angiography
Breast surface radiation dose during coronary CT angiography: Reduction by breast displacement and lead shielding. AJR, August 2011, vol. 197(2), p. 367-373.
Foley, SJ, et al.
http://www.ajronline.org/content/197/2/367.abstract?rss=1
The purpose of this study was to prospectively evaluate the effect of cranial breast displacement and lead shielding on in vivo breast surface radiation dose in women undergoing coronary CT angiography.
Foley, SJ, et al.
http://www.ajronline.org/content/197/2/367.abstract?rss=1
The purpose of this study was to prospectively evaluate the effect of cranial breast displacement and lead shielding on in vivo breast surface radiation dose in women undergoing coronary CT angiography.
Microcalcifications around a collegen-based breast biopsy marker: complication of biopsy with a percutaneous marking system
Microcalcifications around a collegen-based breast biopsy marker: complication of biopsy with a percutaneous marking system. AJR, August 2011, vol. 197(2), p.W353 - W357
Trop, I., et al.
http://www.ajronline.org/content/197/2/W353.abstract?rss=1
The purpose of this article is to present the cases of four women who underwent percutaneous breast biopsy with deployment of a titanium metallic marker embedded in a bioresorbable collagen plug. Routine follow-up mammography after benign pathologic results were obtained revealed new fine microcalcifications at the biopsy sites, requiring repeat biopsy. Pathologic examination confirmed the presence of microcalcifications associated with an acidophilic foreign material.
Trop, I., et al.
http://www.ajronline.org/content/197/2/W353.abstract?rss=1
The purpose of this article is to present the cases of four women who underwent percutaneous breast biopsy with deployment of a titanium metallic marker embedded in a bioresorbable collagen plug. Routine follow-up mammography after benign pathologic results were obtained revealed new fine microcalcifications at the biopsy sites, requiring repeat biopsy. Pathologic examination confirmed the presence of microcalcifications associated with an acidophilic foreign material.
Flat epithelial atypia of the breast: pathological-radiological correlation
Flat epithelial atypia of the breast: pathological-radiological correlation. AJR, Sept 2011, vol. 197(3), p. 740-746.
Solorzano, S., et al.
http://www.ajronline.org/content/197/3/740.abstract?rss=1
This study was undertaken to determine the prevalence of flat epithelial atypia at ultrasound-guided and stereotactically guided needle biopsies, to describe the mammographic and sonographic features of flat epithelial atypia, and to determine the significance of lesions diagnosed as flat epithelial atypia at imaging-guided needle biopsies.
Solorzano, S., et al.
http://www.ajronline.org/content/197/3/740.abstract?rss=1
This study was undertaken to determine the prevalence of flat epithelial atypia at ultrasound-guided and stereotactically guided needle biopsies, to describe the mammographic and sonographic features of flat epithelial atypia, and to determine the significance of lesions diagnosed as flat epithelial atypia at imaging-guided needle biopsies.
Supplemental use of optical diffusion breast imaging for differentiation between benign and malignant breast lesions
Supplemental use of optical diffusion breast imaging for differentiation between benign and malignant breast lesions. AJR, Sept 2011, vol. 197(3), p. 732-739.
Moon, JH, et al.
http://www.ajronline.org/content/197/3/732.abstract?rss=1
The objective of this study was to prospectively evaluate the diagnostic accuracy of optical diffusion breast imaging in patients who underwent conventional ultrasound followed by surgery or biopsy.
Moon, JH, et al.
http://www.ajronline.org/content/197/3/732.abstract?rss=1
The objective of this study was to prospectively evaluate the diagnostic accuracy of optical diffusion breast imaging in patients who underwent conventional ultrasound followed by surgery or biopsy.
Image guided preoperative hookwire localization of nonpalpable extramammory lesions
Image guided preoperative hookwire localization of nonpalpable extramammory lesions. AJR, Sept 2011, vol. 197(3), p. W525-W527
Kelan, KJ, et al.
http://www.ajronline.org/content/197/3/W525.abstract?rss=1
Imaging-guided hookwire localization of nonpalpable lesions in the breast is frequently performed preoperatively. Outside the breast, this procedure is useful for planning resection of lesions in anatomic regions without intrinsic landmarks. The purpose of this study was to review an experience with hookwire localization of nonpalpable extramammary lesions.
Kelan, KJ, et al.
http://www.ajronline.org/content/197/3/W525.abstract?rss=1
Imaging-guided hookwire localization of nonpalpable lesions in the breast is frequently performed preoperatively. Outside the breast, this procedure is useful for planning resection of lesions in anatomic regions without intrinsic landmarks. The purpose of this study was to review an experience with hookwire localization of nonpalpable extramammary lesions.
Wednesday, 3 August 2011
Management of uncommon chemotherapy-induced emergencies
Management of uncommon chemotherapy-induced emergencies. The Lancet Oncology, Aug 2011, vol. 12(8), p.806-814.
Morgan, C., et al.
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(10)70208-4/abstract?rss=yes
Chemotherapy can induce various clinical emergencies. Prompt recognition and management of these adverse events are important for avoiding further morbidity and mortality.
Morgan, C., et al.
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(10)70208-4/abstract?rss=yes
Chemotherapy can induce various clinical emergencies. Prompt recognition and management of these adverse events are important for avoiding further morbidity and mortality.
Mastectomy and reconstruction in stage IV breast cancer
Mastectomy and reconstruction in stage IV breast cancer: A survery of UK breast and plastic surgeons. The Breast, Aug 2011, vol. 20(4), p.373-79.
Durrant, CAT, et al.
http://www.thebreastonline.com/article/PIIS0960977611000452/abstract?rss=yes
The number of women with stage IV disease who have breast reconstruction is small. The primary aim of this study was to examine opinions as to the appropriateness of breast reconstruction in this group.
Durrant, CAT, et al.
http://www.thebreastonline.com/article/PIIS0960977611000452/abstract?rss=yes
The number of women with stage IV disease who have breast reconstruction is small. The primary aim of this study was to examine opinions as to the appropriateness of breast reconstruction in this group.
Subscribe to:
Posts (Atom)