Thursday, 28 February 2019

EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer



 by Steven A. Buechler, Yesim Gökmen–Polar, Sunil S. Badve  

The Breast: February 2019, Volume 43, Pages 74-80

Highlights:
•EarlyR gene signature uses expression of 5 genes to stratify ER + breast cancer patients by prognosis.
•EarlyR has been previously validated in 2 randomized clinical trials.
•The current study documents the ability of EarlyR to predict pathological complete response (pCR).
•EarlyR predicts survival in NACT-treated ER + patients.
•EarlyR is both a prognostic assay and a predictive assay.