Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study
Copson ,E et al
Lancet Oncology Volume 19, No. 2, p169–180, February 2018
Patients with young-onset breast cancer who carry a BRCA mutation have similar survival as non-carriers. However, BRCA mutation carriers with triple-negative breast cancer might have a survival advantage during the first few years after diagnosis compared with non-carriers. Decisions about timing of additional surgery aimed at reducing future second primary-cancer risks should take into account patient prognosis associated with the first malignancy and patient preferences.
