Thursday 28 May 2015

Clinical outcomes of women with breast cancer and a PALB2 mutation

Clinical outcomes of women with breast cancer and a PALB2 mutation: a prospective cohort analysis. The Lancet Oncology, June 2015, Vol. 16(6), p.638-44.

Cybulski, C., et al.

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)70142-7/fulltext?rss=yes

Mutations in PALB2 predispose to breast cancer, but the effect on prognosis of carrying a PALB2mutation has not been ascertained. We aimed to estimate the odds ratio for breast cancer in women with an inherited mutation in PALB2 and 10-year survival after breast cancer in patients who carry aPALB2 mutation.