Anxiety after an abnormal screening mammography is a serious problem. The Breast, Vol. 21(1), Feb. 2012, p. 83-88.
Keyzer-Dekker, C.M.G., et al.
http://www.sciencedirect.com/science/article/pii/S0960977611003213
The aim of this study was to analyze the possible negative psychological consequences of a false positive screening mammogram (FPSM). We compared anxiety evoked by first (FSM) versus repeat screening mammogram (RSM). Questionnaires were completed prior to the diagnosis and during follow up.
Tuesday, 7 February 2012
The decline in breast cancer mortality in Europe
The decline in breast cancer mortality in Europe: An update to 2009. The Breast, Vol. 21(1), Feb. 2012, p. 77-82.
Bosetti, C., et al.
http://www.sciencedirect.com/science/article/pii/S0960977611001688
We updated trends in breast cancer mortality in Europe up to the late 2000’s. In the EU, age-adjusted (world standard population) breast cancer mortality rates declined by 6.9% between 2002 and 2006, from 17.9 to 16.7/100,000. The largest falls were in northern European countries, but more recent declines were also observed in central and eastern Europe.
Bosetti, C., et al.
http://www.sciencedirect.com/science/article/pii/S0960977611001688
We updated trends in breast cancer mortality in Europe up to the late 2000’s. In the EU, age-adjusted (world standard population) breast cancer mortality rates declined by 6.9% between 2002 and 2006, from 17.9 to 16.7/100,000. The largest falls were in northern European countries, but more recent declines were also observed in central and eastern Europe.
A pilot study to examine the experiences and attitudes of women with breast cancer towards one versus two-step axillary surgery
A pilot study to examine the experiences and attitudes of women with breast cancer towards one versus two-step axillary surgery. The Breast, Vol 21(1), Feb 2012, p. 72-76.
Jenkins, V., et al.
http://www.sciencedirect.com/science/article/pii/S096097761100292X
Women generally were unaware about their lymph nodes, what their function is and how they are removed. Preference was indicated for intra-operative sentinel lymph node biopsy (SLNB) analysis provided clear descriptions were given about the risk of experiencing false negative and false positive results.
Jenkins, V., et al.
http://www.sciencedirect.com/science/article/pii/S096097761100292X
Women generally were unaware about their lymph nodes, what their function is and how they are removed. Preference was indicated for intra-operative sentinel lymph node biopsy (SLNB) analysis provided clear descriptions were given about the risk of experiencing false negative and false positive results.
Imaging sensitivity of dedicated positron emission mammography in relation to tumour size
Imaging sensitivity of dedicated positron emission mammography in relation to tumour size. The Breast, Vol. 21(1), Feb. 2012, p. 66-71.
Eo, J.S., et al.
http://www.sciencedirect.com/science/article/pii/S096097761100169X
Positron emission mammography (PEM) has been reported to have higher sensitivity than whole-body positron emission tomography (PET)due to higher spatial resolution. However, no direct evidence exists regarding the imaging sensitivity of PEM related to lesion size. In the present study, imaging sensitivity of PEM was investigated in relation to pathologically confirmed tumor size.
Eo, J.S., et al.
http://www.sciencedirect.com/science/article/pii/S096097761100169X
Positron emission mammography (PEM) has been reported to have higher sensitivity than whole-body positron emission tomography (PET)due to higher spatial resolution. However, no direct evidence exists regarding the imaging sensitivity of PEM related to lesion size. In the present study, imaging sensitivity of PEM was investigated in relation to pathologically confirmed tumor size.
Re-evaluating the role of axillary lymph node dissection in screen-detected breast cancer patients
Re-evaluating the role of axillary lymph node dissection in screen-detected breast cancer patients. The Breast, Vol. 21(1), Feb 2012, p. 58-60.
Barry, M. & Kell, M.R.
http://www.sciencedirect.com/science/article/pii/S0960977611001640
The American College of Surgeons Oncology Group (ACOSOG), Z0011 trial, demonstrated that there was no therapeutic benefit from completion lymphadenectomy in early stage breast cancer patients with positive sentinel node (SLN) biopsy. Patients with asymptomatic screen-detected tumors may represent a subgroup where completion axillary dissection with its attendant morbidities is unacceptable. Therefore, the aim of this study was to evaluate the role of ALND in an asymptomatic screen-detected breast cancer cohort.
Barry, M. & Kell, M.R.
http://www.sciencedirect.com/science/article/pii/S0960977611001640
The American College of Surgeons Oncology Group (ACOSOG), Z0011 trial, demonstrated that there was no therapeutic benefit from completion lymphadenectomy in early stage breast cancer patients with positive sentinel node (SLN) biopsy. Patients with asymptomatic screen-detected tumors may represent a subgroup where completion axillary dissection with its attendant morbidities is unacceptable. Therefore, the aim of this study was to evaluate the role of ALND in an asymptomatic screen-detected breast cancer cohort.
Relationship between body mass index and preoperative treatment response to aromatase inhibitor exemestane in postmenopausal patients
Relationship between body mass index and preoperative treatment response to aromatase inhibitor exemestane in postmenopausal patients with primary breast cancer. The Breast, Vol. 21(1), Feb. 2012, p. 40-45.
Takada, M., et al.
Some studies have shown that high body mass index (BMI) is associated with inferior outcome after adjuvant therapy with anastrozole in breast cancer patients. We aimed to investigate predictive effect of BMI on clinical response to neoadjuvant therapy with exemestane in postmenopausal patients with primary breast cancer.
Takada, M., et al.
Some studies have shown that high body mass index (BMI) is associated with inferior outcome after adjuvant therapy with anastrozole in breast cancer patients. We aimed to investigate predictive effect of BMI on clinical response to neoadjuvant therapy with exemestane in postmenopausal patients with primary breast cancer.
Bone health management with patients with breast cancer
Bone health management with patients with breast cancer: Current standards and emerging strategies. The Breast Vol. 21(1), Feb 2012, p. 8-19.
Aapro, M.S. & Coleman, R.E.
http://www.sciencedirect.com/science/article/pii/S0960977611003225
In women who develop bone metastases from breast cancer (BC), interactions between tumor cells and osteoclasts within the bone lead to localized bone destruction and increase the risk of skeletal-related events (SREs). Bisphosphonates inhibit osteoclast-mediated bone resorption, and have been used extensively for treating post-menopausal osteoporosis and reducing the risk of SREs in patients with bone metastases. A number of clinical trials in women with early stage BC have demonstrated that adding bisphosphonates to adjuvant endocrine therapy can prevent bone loss and may prevent disease recurrence and improve disease-free survival.
Aapro, M.S. & Coleman, R.E.
http://www.sciencedirect.com/science/article/pii/S0960977611003225
In women who develop bone metastases from breast cancer (BC), interactions between tumor cells and osteoclasts within the bone lead to localized bone destruction and increase the risk of skeletal-related events (SREs). Bisphosphonates inhibit osteoclast-mediated bone resorption, and have been used extensively for treating post-menopausal osteoporosis and reducing the risk of SREs in patients with bone metastases. A number of clinical trials in women with early stage BC have demonstrated that adding bisphosphonates to adjuvant endocrine therapy can prevent bone loss and may prevent disease recurrence and improve disease-free survival.
Tamoixfen increases the risk of microvascular flap complications in patients undergoing microvascular breast reconstruction
Tamoixfen increases the risk of microvascular flap complications in patients undergoing microvascular breast reconstruction. Plastic & reconstructive surgery, Feb 2012, Vol. 129(2), p. 305-314.
Kelley, B.P., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2012/02000/Tamoxifen_Increases_the_Risk_of_Microvascular_Flap.3.aspx
Tamoxifen citrate (tamoxifen) has been associated with increased rates of thromboembolic events, prompting concerns that it may increase the risk of complications after microvascular breast reconstruction. Some centers have implemented protocols to temporarily stop tamoxifen before microvascular breast reconstruction. The authors sought to determine whether this practice is warranted.
Kelley, B.P., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2012/02000/Tamoxifen_Increases_the_Risk_of_Microvascular_Flap.3.aspx
Tamoxifen citrate (tamoxifen) has been associated with increased rates of thromboembolic events, prompting concerns that it may increase the risk of complications after microvascular breast reconstruction. Some centers have implemented protocols to temporarily stop tamoxifen before microvascular breast reconstruction. The authors sought to determine whether this practice is warranted.
Fat grafting and breast reconstruction with implant
Fat grafting and breast reconstruction with implant: Another option for irradiated breast cancer patients. Plastic & reconstructive surgery, Feb. 2012 Vol. 129(2), p.317-329.
Salgarello, M., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2012/02000/Fat_Grafting_and_Breast_Reconstruction_with.5.aspx
In postmastectomy radiated patients, autologous tissue reconstruction is preferred over implant reconstruction, because the latter is associated with a higher rate of postoperative complications. Autologous tissue reconstruction, however, is not always feasible and is sometimes refused by the patient.
Salgarello, M., et al.
http://journals.lww.com/plasreconsurg/Fulltext/2012/02000/Fat_Grafting_and_Breast_Reconstruction_with.5.aspx
In postmastectomy radiated patients, autologous tissue reconstruction is preferred over implant reconstruction, because the latter is associated with a higher rate of postoperative complications. Autologous tissue reconstruction, however, is not always feasible and is sometimes refused by the patient.
Thursday, 12 January 2012
Prosthesis salvage in breast reconstruction patients with periprosthetic infection and exposure
Prosthesis salvage in breast reconstruction patients with periprosthetic infection and exposure. Plastic and reconstructive surgery, Jan 2012, Vol. 129 (1), p.42-48.
Prince, M.D., et al.
http://journals.lww.com/plasreconsurg/Abstract/2012/01000/Prosthesis_Salvage_in_Breast_Reconstruction.10.aspx
Breast prosthesis reconstruction continues to be the most common form of breast reconstruction, and infection and exposure remain major concerns for patients and surgeons. The data from the authors' results provide additional tools for patient selection and treatment, and offer a simplified management protocol for breast reconstruction patients with infected and/or exposed breast prostheses.
Prince, M.D., et al.
http://journals.lww.com/plasreconsurg/Abstract/2012/01000/Prosthesis_Salvage_in_Breast_Reconstruction.10.aspx
Breast prosthesis reconstruction continues to be the most common form of breast reconstruction, and infection and exposure remain major concerns for patients and surgeons. The data from the authors' results provide additional tools for patient selection and treatment, and offer a simplified management protocol for breast reconstruction patients with infected and/or exposed breast prostheses.
Thursday, 15 December 2011
Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer
Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8.1 years median follow-up. The Lancet Oncology, Vol. 12(12), Nov 2011, p. 1101-1108.
Regan, M.M., et al.
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(11)70270-4/abstract?rss=yes
Postmenopausal women with hormone receptor-positive early breast cancer have persistent, long-term risk of breast-cancer recurrence and death. Therefore, trials assessing endocrine therapies for this patient population need extended follow-up. We present an update of efficacy outcomes in the Breast International Group (BIG) 1-98 study at 8·1 years median follow-up.
Regan, M.M., et al.
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(11)70270-4/abstract?rss=yes
Postmenopausal women with hormone receptor-positive early breast cancer have persistent, long-term risk of breast-cancer recurrence and death. Therefore, trials assessing endocrine therapies for this patient population need extended follow-up. We present an update of efficacy outcomes in the Breast International Group (BIG) 1-98 study at 8·1 years median follow-up.
Influence of histology on the effectiveness of adjuvant chemotherapy
Influence of histology on the effectiveness of adjuvant chemotherapy in patients with hormone receptor positive invasive breast cancer. The Breast, Vol. 20(6), Dec 2011, p. 505-509.
Truin, W., et al.
http://www.thebreastonline.com/article/S0960-9776(11)00121-4/abstract
To investigate the effect of adjuvant chemotherapy on long term survival in addition to hormonal therapy in the systemic treatment of hormonal receptor positive breast cancer patients.
Truin, W., et al.
http://www.thebreastonline.com/article/S0960-9776(11)00121-4/abstract
To investigate the effect of adjuvant chemotherapy on long term survival in addition to hormonal therapy in the systemic treatment of hormonal receptor positive breast cancer patients.
Trastuzumab combined to neoadjuvant chemotherapy in patients with HER2-positive breast cancer
Trastuzumab combined to neoadjuvant chemotherapy in patients with HER2-positive breast cancer: A systematic review and meta-analysis. The Breast Vol. 20(6), Dec 2011, p. 485-490.
Valachis, A., et al.
http://www.thebreastonline.com/article/S0960-9776(11)00135-4/abstract
Potentially eligible trials were located through PubMed and Cochrane Library searches and abstracts of major international conferences. The endpoints that we assessed were pathologic complete response (pCR) rate, breast-conserving surgery (BCS) rate and toxicity.
Valachis, A., et al.
http://www.thebreastonline.com/article/S0960-9776(11)00135-4/abstract
Potentially eligible trials were located through PubMed and Cochrane Library searches and abstracts of major international conferences. The endpoints that we assessed were pathologic complete response (pCR) rate, breast-conserving surgery (BCS) rate and toxicity.
Intraveneous fluid infusion rate in microsurgical breast reconstruction
Intraveneous fluid infusion rate in microsurgical breast reconstruction: Important lessons learned from 354 free flaps. Plastic & reconstructive surgery, Dec 2011, Vol. 128(6), p. 1153-1160.
Zhong, T., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/12000/Intravenous_Fluid_Infusion_Rate_in_Microsurgical.1.aspx
The purpose of this study was to determine the role of intravenous fluid infusion rate in the development of in-hospital complications in patients undergoing microsurgical breast reconstruction for breast cancer.
Zhong, T., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/12000/Intravenous_Fluid_Infusion_Rate_in_Microsurgical.1.aspx
The purpose of this study was to determine the role of intravenous fluid infusion rate in the development of in-hospital complications in patients undergoing microsurgical breast reconstruction for breast cancer.
Simultaneous scarless contralateral breast augmentation
Simultaneous scarless contralateral breast augmentation during unilateral breast reconstruction using bilateral differentially split DIEP flaps. Plastic & reconstructive surgery, Dec 2011, Vol 128(6), p. 593e-604e.
Huang, J-J., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/12000/Simultaneous_Scarless_Contralateral_Breast.6.aspx
Simultaneous contralateral augmentation is performed with unilateral breast reconstruction to achieve pleasing and symmetric breast mounds. This prospective study investigated the outcome of simultaneous scarless contralateral augmentation with unilateral breast reconstruction using bilateral differentially split deep inferior epigastric perforator (DIEP) flaps.
Huang, J-J., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/12000/Simultaneous_Scarless_Contralateral_Breast.6.aspx
Simultaneous contralateral augmentation is performed with unilateral breast reconstruction to achieve pleasing and symmetric breast mounds. This prospective study investigated the outcome of simultaneous scarless contralateral augmentation with unilateral breast reconstruction using bilateral differentially split deep inferior epigastric perforator (DIEP) flaps.
The lateral chest wall: A separate aesthetic unit in breast surgery
The lateral chest wall: A separate aesthetic unit in breast surgery. Plastic and reconstructive surgery; Dec 2011, Vol. 128(6), p. 626e - 643e.
Bar-Meir, E.D., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/12000/The_Lateral_Chest_Wall___A_Separate_Aesthetic_Unit.13.aspx
The lateral chest wall is an aesthetic unit often overlooked in breast surgery. Abnormalities are often seen in candidates for aesthetic and reconstructive breast surgery and in the massive weight loss population. Preoperative evaluation of the lateral chest wall is necessary to address this area properly.
Bar-Meir, E.D., et al.
http://journals.lww.com/plasreconsurg/Abstract/2011/12000/The_Lateral_Chest_Wall___A_Separate_Aesthetic_Unit.13.aspx
The lateral chest wall is an aesthetic unit often overlooked in breast surgery. Abnormalities are often seen in candidates for aesthetic and reconstructive breast surgery and in the massive weight loss population. Preoperative evaluation of the lateral chest wall is necessary to address this area properly.
Pertuzumab plus Trastuzumab plus Docetaxel for metastatic breast cancer
Pertuzumab plus Trastuzumab plus Docetaxel for metastatic breast cancer. N Eng J Med, Dec 2011.
Baselga, J., et al.
http://www.nejm.org/doi/full/10.1056/NEJMoa1113216#t=article
The anti–human epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody trastuzumab improves the outcome in patients with HER2-positive metastatic breast cancer. However, most cases of advanced disease eventually progress.
Baselga, J., et al.
http://www.nejm.org/doi/full/10.1056/NEJMoa1113216#t=article
The anti–human epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody trastuzumab improves the outcome in patients with HER2-positive metastatic breast cancer. However, most cases of advanced disease eventually progress.
Evedrolimus in postmenopausal hormone-receptor-positive advanced breast cancer
Evedrolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Eng J. Med, Dec 2011
Baselga, J., et al.
http://www.nejm.org/doi/full/10.1056/NEJMoa1109653#t=article
Endocrine therapy is the cornerstone of treatment for patients with hormone-receptor (HR)–positive advanced breast cancer. In postmenopausal patients, aromatase inhibitors (e.g., letrozole and anastrozole) have become the treatment of choice in first-line therapy. Unfortunately, not all patients have a response to first-line endocrine therapy (primary or de novo resistance), and even patients who have a response will eventually relapse (acquired resistance).
Baselga, J., et al.
http://www.nejm.org/doi/full/10.1056/NEJMoa1109653#t=article
Endocrine therapy is the cornerstone of treatment for patients with hormone-receptor (HR)–positive advanced breast cancer. In postmenopausal patients, aromatase inhibitors (e.g., letrozole and anastrozole) have become the treatment of choice in first-line therapy. Unfortunately, not all patients have a response to first-line endocrine therapy (primary or de novo resistance), and even patients who have a response will eventually relapse (acquired resistance).
Disappearance of a breast prosthesis during Pilates
Disappearance of a breast prosthesis during Pilates. N Eng J Med., 2011, 365:2305
Fong, T.C., and Hoffmann, B.
http://www.nejm.org/doi/full/10.1056/NEJMicm1102594
A 59-year-old woman with a history of breast cancer who underwent bilateral mastectomy and placement of breast prostheses presented for evaluation, reporting that her “body swallowed one of the implants” during a Pilates stretching exercise.
Fong, T.C., and Hoffmann, B.
http://www.nejm.org/doi/full/10.1056/NEJMicm1102594
A 59-year-old woman with a history of breast cancer who underwent bilateral mastectomy and placement of breast prostheses presented for evaluation, reporting that her “body swallowed one of the implants” during a Pilates stretching exercise.
Minor influence of self-selection bias on the effectiveness of breast cancer screening in case-control studies in the Netherlands
Minor influence of self-selection bias on the effectiveness of breast cancer screening in case-control studies in the Netherlands. Journal of medical screening, Sept 2011, Vol. 18(3), p. 142-146
Paap, E., et al.
http://jms.rsmjournals.com/content/18/3/142.short?rss=1
Self-selection bias is considered to be a problem when evaluating the effectiveness of breast cancer service screening in case-control studies. Using the incidence-based mortality method (IBM), a correction factor for the potential influence of self-selection can be derived from a group of non-screened women and a group of not-invited women.
Paap, E., et al.
http://jms.rsmjournals.com/content/18/3/142.short?rss=1
Self-selection bias is considered to be a problem when evaluating the effectiveness of breast cancer service screening in case-control studies. Using the incidence-based mortality method (IBM), a correction factor for the potential influence of self-selection can be derived from a group of non-screened women and a group of not-invited women.
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