by Rastogi, Pratik; Riordan,
Edward; Moon, David; Deva, Anand K.
Summary:
Breast implant–associated anaplastic large cell lymphoma is a malignancy of T
lymphocytes that is associated with the use of textured breast implants in both
esthetic and reconstructive surgeries. Patients typically present with a
delayed seroma 8–10 years following implantation or—less commonly—with a
capsular mass or systemic disease. Current theories on disease pathogenesis
focus on the interplay among textured implants, Gram-negative bacteria, host
genetics, and time. The possible roles of silicone leachables and particles
have been less well substantiated. This review aims to synthesize the existing
scientific evidence regarding breast implant–associated anaplastic large cell lymphoma
etiopathogenesis.
