Monday, 18 November 2013

The sex hormone system in carriers of BRCA1/2 mutations

The sex hormone system in carriers of BRCA 1/2 mutations: a case-control study. The lancet oncology, Nov 2013, Vol. 13(12), 1226-32.

Widschwendter, M., et al.

Penetrance for breast cancer, ovarian cancer, or both in carriers of BRCA1/BRCA2 mutations is disproportionately high. Sex hormone dysregulation and altered end-organ hormone sensitivity might explain this organ-specific penetrance. We sought to identify differences in hormone regulation between carriers of BRCA1/2 and women who are negative for BRCA1/2 mutations.