Combination endocrine treatments unproven in breast cancer. The lancet oncology, Sept 2013, Vol. 14(10), p.917-18.
Buzdar, A.U.
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70364-4/fulltext?_eventId=login&rss=yes
Ovarian ablation, which was introduced more than 100 years ago, was the first endocrine treatment for advanced breast cancer, followed by adrenalectomy and hypophysectomy. These ablative therapies have since been replaced by antioestrogen treatments, luteinising-hormone-releasing hormone agonists, and aromatase inhibitors.Other endocrine treatments with different mechanisms of action have also become available for breast cancer: oestrogens, progestins, androgens, antiandrogens, and selective oestrogen-receptor downregulators.
