Association between treatment with brachytherapy vs whole breast irradiation and subsequent mastectomy, complications, and survival among older women with invasive breast cancer. JAMA, 2012, Vol. 307(17), p.1827-1837.
Smith, G.L., et al.
http://jama.ama-assn.org/content/307/17/1827.short?rss=1
Brachytherapy is a radiation treatment that uses an implanted radioactive source. In recent years, use of breast brachytherapy after lumpectomy for early breast cancer has increased substantially despite a lack of randomized trial data comparing its effectiveness with standard whole-breast irradiation (WBI).