The Breast journal Vol 15 Iss 2 2009

Early View (Articles Available Online in Advance of Print)
EDITORIAL
117-119
Therapeutic Decisions for Ductal Carcinoma In Situ:
A Gordian KnotMichael Lagios
AbstractPublished Online: 9 Mar 2009DOI 10.1111/j.1524-4741.2009.00685.x

ORIGINAL ARTICLES
120-132
Prognostic Significance of Oncogenic Markers in Ductal Carcinoma In Situ of the Breast: A Clinicopathologic Study
Sevilay Altintas, Kathleen Lambein, Manon T. Huizing, Geert Braems et al
AbstractPublished Online: 9 Mar 2009

133-139
Early Detection of Breast Cancer through Population-Based Mammographic Screening in Asian Women: A Comparison Study between Screen-Detected and Symptomatic Breast Cancers
Esther W. L. Chuwa, Allen W. Y. Yeo, Heng Nung Koong et al
AbstractPublished Online: 9 Mar 2009

140-145
Intraoperative High-Dose-Rate Brachytherapy—A Novel Technique in the Surgical Management of Axillary Recurrence
Manjeet Chadha, Par Mehta, Sheldon Feldman, Susan K. Boolbol, Louis B. Harrison
AbstractPublished Online: 9 Mar 2009

146-154
Should Histologic Type be Taken into Account when Considering Neoadjuvant Chemotherapy in Breast Carcinoma?
Peggy S. Sullivan, Sophia K. Apple
AbstractPublished Online: 9 Mar 2009

155-162
Identification and Management of Women at High Risk for Hereditary Breast/Ovarian Cancer Syndrome
Elissa M. Ozanne, Andrea Loberg, Sherwood Hughes, Christine Lawrence et al
AbstractPublished Online: 9 Mar 2009

163-167
Locoregional Relapse After Breast Cancer: Most Relapses Occur Late and are not Clinically Detected
David A. Montgomery, Katherine Krupa, Timothy G. Cooke
AbstractPublished Online: 9 Mar 2009

168-175
Fiberoptic Ductoscopy-Guided Intraductal Biopsy Improve the Diagnosis of Nipple Discharge
Hong Ling, Guang-yu Liu, Jin-song Lu, Susan Love, Jia-xin Zhang, Xiao-li Xu et al
AbstractPublished Online: 9 Mar 2009

176-181
Primary Peritoneal Serous Carcinoma Presenting as Inflammatory Breast Cancer
Ibrahim Khalifeh, Michael T. Deavers, Massimo Cristofanilli, Robert L. Coleman, Anais Malpica, Michael Z. Gilcrease
AbstractPublished Online: 9 Mar 2009

182-188
Breast Cancer in the Middle Eastern Population of California, 1988–2004
Kiumarss Nasseri
AbstractPublished Online: 9 Mar 2009

SHORT COMMUNICATIONS
189-193
MRI of the Breast: Does the Internet Accurately Report its Beneficial Uses and Limitations?
Larissa Nekhlyudov, Keith Kiarsis, Joann G. Elmore
AbstractPublished Online: 9 Mar 2009

194-198
Enhancing the Adjuvant Treatment of Hormone Receptor Positive Breast Cancer
Mitchel Barry, Malcolm R. Kell
AbstractPublished Online: 9 Mar 2009

CASE REPORT
199-201
First Report of a Necrotising Fasciitis of the Breast Following a Core Needle Biopsy
Anaig Flandrin, Caroline Rouleau, Chaible Azar, Olivier Dubon, Pierre Ludovic Giacalone
AbstractPublished Online: 9 Mar 2009

BREAST IMAGES
202-203
Metastatic Breast Cancer Presenting as Cancer of Unknown Primary Associated with Superior Vena Cava Syndrome
Hyun-Jeong Shim, Se-Ryeon Lee, Jae-Sok Ahn, Duk-Hwan Yang et al
AbstractPublished Online: 9 Mar 2009

203-205
Synchronous Primary Breast and Ovarian Cancer with Ovarian Cancer Metastases to a Breast Sentinel Lymph Node
Erin F. Wolff, Maritza Martel, Katja Gwin, Donald Lannin
AbstractPublished Online: 9 Mar 2009

205-206
Solid Neuroendocrine Carcinoma of the Breast with Osteoclast-Like Giant Cells
Oluwole Fadare, Stephen A. Gill
AbstractPublished Online: 9 Mar 2009

206-207
Primary Well Differentiated Liposarcoma: An Unusual Tumor in the Breast
Lamia Charfi, Maha Driss, Karima Mrad, Imen Abbes, Rym Dhouib, Samia Sassi, Khaled Ben Romdhane
AbstractPublished Online: 9 Mar 2009

208-209
Spider Bite on a Male Breast: A Rare Case in the Capital
Flora Zagouri, Theodoros N. Sergentanis, Nikolaos V. Michalopoulos, Aphrodite Nonni, Georgia Giannakopoulou, George C. Zografos
AbstractPublished Online: 9 Mar 2009

LETTERS TO THE EDITOR
210-211
Precipitating Factors for Lymphedema Following Surgical Treatment of Breast Cancer: Implications for Patients Undergoing Axillary Lymph Node Dissection
Murat Dayangac, Özer Makay, Levent Yeniay, Murat Aynaci, Murat Kapkac, Rasih Yilmaz
AbstractPublished Online: 9 Mar 2009

212-213
Isolated Tumor Cells in Bone Marrow and its Relation with known Prognostic Factors in Breast Cancer Patients
Renata Sánchez, Luis González, Luis Betancourt, Juan J. Rodríguez et al
AbstractPublished Online: 9 Mar 2009

214-215
Vacuum-Assisted Closure Dressing as an Aid to Salvage Breast Following Severe Postoperative Infection
Shakeel Dustagheer, Mel Tohill B, Khalid Khan
AbstractPublished Online: 9 Mar 2009

216-217
Travel Distance to Mammography and the Early Detection of Breast Cancer
Anneke T. Schroen, Megan E. Lohr
AbstractPublished Online: 9 Mar 2009

218-220
Dendritic Cell Infiltration in Lymph Node Positive Breast Carcinomas
Huiying He, G Somlo, Yen Yun, Peiguo G Chu
AbstractPublished Online: 9 Mar 2009

Annals of Surgery March 2009 Vol 249 Iss 3

448-454
Impact of MRI-Evaluated Neoadjuvant Chemotherapy Response on Change of Surgical Recommendation in Breast Cancer
Jeon-Hor Chen, MD; Byron A. Feig, BS; David J-B Hsiang, MD; John A. Butler, MD; Rita S. Mehta, MD; Shadfar Bahri, MD; Orhan Nalcioglu, PhD; Min-Ying Su, PhD

455-460
Can Sentinel Node Biopsy Be Avoided in Some Elderly Breast Cancer Patients?
for the North American Fareston Tamoxifen Adjuvant Trial

461-468
The Oncological Safety of Skin Sparing Mastectomy with Conservation of the Nipple-Areola Complex and Autologous Reconstruction: An Extended Follow-Up Study
Bernd Gerber, MD, PhD; Annette Krause, MD; Max Dieterich, MD; Günther Kundt, PhD,†; Toralf Reimer, MD, PhD

BMJ 24 Feb 2009

Editorial
Minimally invasive surgery for breast cancer
Monica Morrow
BMJ 2009;338 b557

News
Breast cancer incidence falls as women give up HRT
Roger Dobson
BMJ 2009;338 b791

Familial breast cancer - NICE

Familial breast cancer
NICE guideline October 2006
Summary
The NICE clinical guideline on familial breast cancer covers the care of adult women who may be at increased risk of developing breast cancer because of a family history of breast or other cancers.
It does not specifically look at: women who have already been diagnosed with breast cancer or men, but the recommendations may be relevant to some men because, although rarer than in women, men may get breast cancer and this may run in families.
This guideline is an update of advice on familial breast cancer that NICE produced in 2004. The advice on magnetic resonance imaging (MRI) for breast cancer screening has changed, but all the other advice is the same.

Articles from Cases Journal

Cutaneous metastases of breast carcinoma: a case report
Vano-Galvan S, Moreno-Martin P, Salguero I, Jaen P
Cases Journal 2009, 2:71 (21 January 2009)
[Abstract] [Provisional PDF]

''Signt-ring'' cell invasive lobular carcinoma of the breast - accidental finding associated with intraductal papilloma: a case report
Blazicevic V, Staklenac B, Kristek J, Pajtler M, Krajinovic Z, Stimac D, Ivezic Z, Kotromanovic Z, Tomas I, Biljan M
Cases Journal 2009, 2:130 (6 February 2009)
[Abstract] [Provisional PDF]

Breast Reconstruction after Breast-Cancer Surgery

New England Journal of Medicine
Volume 360, Issue 4: January 22, 2009
CORRESPONDENCE
Breast Reconstruction after Breast-Cancer Surgery
Beier, Horsch and Bach

AJR March 2009 Vol. 192 No. 3

Mucinous Carcinoma of the Breast: MRI Features of Pure and Mixed Forms with Histopathologic Correlation
Shuichi Monzawa, Masaki Yokokawa, Toshiko Sakuma, Shintaro Takao et al
AJR 2009;192:125-131
http://www.ajronline.org/cgi/content/abstract/192/3/W125

Digital Mammography-Guided Skin Marking for Sonographically Guided Biopsy of Suspicious Microcalcifications
Nariya Cho and Woo Kyung Moon
AJR 2009;192:132-136
http://www.ajronline.org/cgi/content/abstract/192/3/W132

MRI and PET/CT for Triaging Stage IB Clinically Operable Cervical Cancer to Appropriate Therapy: Decision Analysis to Assess Patient Outcomes
Pari V. Pandharipande, Garry Choy, Marcela G. del Carmen et al
AJR 2009;192:802-814
http://www.ajronline.org/cgi/content/abstract/192/3/802

The Many Faces of Fat Necrosis in the Breast
Jorge L. Taboada, Tanya W. Stephens, Savitri Krishnamurthy, Kathleen R. Brandt, and Gary J. Whitman
AJR 2009;192:815-825
http://www.ajronline.org/cgi/content/abstract/192/3/815

Plastic & Reconstructive Surgery Vol 123 No 2 2009

Blondeel, Phillip N. M.D., Ph.D.; Hijjawi, John M.D.; Depypere, Herman M.D., Ph.D.; Roche, Nathalie M.D.; Van Landuyt, Koenraad M.D., Ph.D.;
Shaping the Breast in Aesthetic and Reconstructive Breast Surgery: An Easy Three-Step Principle
Plastic & Reconstructive Surgery. 123(2):455-462, February 2009.
Abstract
Creating or recreating an aesthetically pleasing breast shape in reconstructive and aesthetic breast surgery is an act that most experienced "breast" surgeons will find self-evident. We propose a simple three-step philosophical and hands-on approach that will make it easier for young and unexperienced plastic surgeons to not only analyze the problematic breast but also come up with an easy surgical strategy to create reproducible results.This is Part I of four parts describing the three-step principle being applied in reconstructive and aesthetic breast surgery. Part I explains how to analyze a problematic breast by understanding the three main anatomical features of a breast and how they interact: the footprint, the conus of the breast, and the skin envelope. Part II deals with reconstructions after complete mastectomy and Part III covers reconstruction after breast conservation surgery. Finally, Part IV applies the same principles in the field of aesthetic breast surgery. Throughout these four parts, the three-step principle will be the red line to fall back on to define the problem and to propose a solution.(C)2009American Society of Plastic Surgeons

Selective Breast Reduction: A Personal Approach with a Central-Superior Pedicle.
Giacomo Datta, M.D.; Salvatore Carlucci, M.D.
SUPPLEMENTAL DIGITAL CONTENT IS AVAILABLE IN THE TEXT.

Septum-Based Mammaplasty: A Surgical Technique Based on Wuringer's Septum for Breast Reduction.
Moustapha Hamdi, M.D., Ph.D.; Koenraad Van Landuyt, M.D., Ph.D.; Patrick Tonnard, M.D.; Alex Verpaele, M.D.; Stan Monstrey, M.D., Ph.D.
SUPPLEMENTAL DIGITAL CONTENT IS AVAILABLE IN THE TEXT.

Controversies in Breast Cancer 2008

Breast Cancer Research has published a collection of short communications from
Controversies in Breast Cancer 2008 held in Edinburgh, UK on 1-2 September 2008.

Cases Journal Dec 2008 - Jan 2009

Primary breast lymphoma: a consideration in an HIV patient when a mass is discovered by screening mammography: a case report
Akinwande O, Paley R
Cases Journal, 2008 1:387 ( 11 December 2008 )
[Abstract] [Provisional PDF]

Accessory nipple reconstruction following a central quadrantectomy: a case report
Magno S, Terribile D, Franceschini G, Fabbri C, Chiesa F, Di Leone A, Masetti R
Cases Journal, 2009 2:32 ( 8 January 2009 )
[Abstract] [Provisional PDF]

Carcinosarcoma of the breast: two case reports and review of the literature
Esses K, Hagmaier R, Blanchard S, Lazarchick J, Riker A
Cases Journal, 2009 2:15 ( 6 January 2009 )
[Abstract] [Provisional PDF] [PubMed]

Annals of Surgery January 2009 vol 249 iss 1

26-32
Total Skin-Sparing Mastectomy: Complications and Local Recurrence Rates in 2 Cohorts of Patients
Elisabeth R. Garwood, BS; Dan Moore, PhD; Cheryl Ewing, MD; E Shelley Hwang, MD; Michael Alvarado et al
Abstract
Purpose: Dissemination of the total skin-sparing mastectomy (TSSM) technique is limited by concerns of nipple viability, flap necrosis, local recurrence risk, and the technical challenge of this procedure. We sought to define the impact of surgical and reconstructive variables on complication rates and assess how changes in technique affect outcomes.
Patients and Methods: We compared the outcomes of TSSM in 2 cohorts of patients. Cohort 1: the first 64 TSSM procedures performed at our institution, between 2001 and 2005. Cohort 2: 106 TSSM performed between 2005 and 2007. Outcomes of cohort 1 were analyzed in 2005. At that time, potential risk factors for complications were identified, and efforts to minimize these risks by altering operative and reconstructive technique were then applied to patients in cohort 2. The impact of these changes on outcomes was assessed. Logistic regression was used to determine the association between predictor variables and adverse outcomes (Stata 10).
Results: The predominant incision type in cohort 2 involved less than a third of the nipple areola complex (NAC), and the most frequent reconstruction technique was tissue expander placement. Between cohort 1 and cohort 2, nipple survival rates rose from 80% to 95% (P = 0.003) and complication rates declined: necrotic complications (30% -> 13%; P = 0.01), implant loss (31% -> 10%; P = 0.005), skin flap necrosis (16%-11%; not significant), and significant infections (17%-9%, not significant). Incisions involving >30% of the NAC (P < 0.001) and reconstruction with autologous tissue (P < 0.001) were independent risk factors for necrotic complications. The local recurrence rate was 0.6% at a median follow-up of 13 months (range, 1-65), with no recurrences in the NAC.
Conclusion: Focused improvement in technique has resulted in the development of TSSM as a successful intervention at our institution that is oncologically safe with high nipple viability and early low rates of recurrence. Identifying factors that contribute to complications and changing surgical and reconstructive techniques to eliminate risk factors has greatly improved outcomes.

87-90
Breast Conserving Surgery for Multifocal Breast Cancer
Woosung Lim, MD; Eun-Hwa Park, MD; Sung-Lim Choi, MD; Jin-Young Seo, MD; Hee-Jung Kim, MD; Mi-Ae Chang et al
Abstract
Objective: The purpose of this study is to examine the oncological safety of breast conserving surgery (BCS) for patients with multifocal breast cancer.
Summary Background Data: Few studies have reported about BCS for multifocal breast cancer. BCS for multifocal cancer has a risk of local failure in previous reports, whereas recent studies reported the feasibility of BCS. However, because all studies have dealt with a small number of patients, multifocal breast cancer is still considered a relative contraindication for BCS.
Methods: This retrospective study includes 478 patients with multifocal breast cancer who underwent BCS or mastectomy and 930 with unifocal cancer who underwent BCS for stage 0-II. Multifocal cancer was defined as 2 or more distinct cancers in the same quadrant. Of 478 patients, 147 underwent BCS and 331 underwent mastectomy. We compared the local recurrence rate (LRR), disease free survival, and overall survival for BCS with mastectomy for multifocal cancer. In addition, the LRR of BCS for multifocal cancer was compared for unifocal cancer.
Results: There is no significant difference in stage distribution and other clinical and pathologic characteristics except Her-2/neu for stage IIA between BCS and mastectomy for multifocal caner. The mean follow-up period was 59.33 months (range, 1.00-177.20) for breast conserving group and 64.98 months (range, 6.23-196.03) for mastectomy group. The 5-year overall survival was 93.38% for BCS and 94.53% for mastectomy (log rank P = 0.208). The 5-year disease-free survival was 89.08% for BCS and 91.88% for mastectomy (log rank P = 0.451). The local failure occurred in 3 (2.0%) of 147 patient underwent BCS, 3 (0.9%) of 331 patients underwent mastectomy (P = 0.378). Compared with BCS for unifocal cancer patients, the LRR of patients with multifocal cancer was not statistically different (2.0% for multifocal, 1.3% for unifocal; P = 0.445).
Conclusions: Our study demonstrates that BCS for multifocal breast cancer is oncologically safe in selected patients.

91-96
Video-Assisted Skin-Sparing Breast-Conserving Surgery for Breast Cancer and Immediate Reconstruction With Autologous Tissue
Hiroo Nakajima, MD, PhD; Ikuya Fujiwara, MD, PhD; Naruhiko Mizuta, MD, PhD; Koichi Sakaguchi, MD, PhD; Yasushi Hachimine, MD

American Journal of Roentgenology Jan 2009

Timed Efficiency of Interpretation of Digital and Film-Screen Screening Mammograms
Tamara Miner Haygood, Jihong Wang, E. Neely Atkinson et al
AJR 2009;192:216-220
http://www.ajronline.org/cgi/content/abstract/192/1/216

Sonographic Surveillance for the Detection of Contralateral Metachronous Breast Cancer in an Asian Population
Min Jung Kim, Eun-Kyung Kim, Jin Young Kwak et al
AJR 2009;192:221-228
http://www.ajronline.org/cgi/content/abstract/192/1/221

Frequency and Upgrade Rates of Atypical Ductal Hyperplasia Diagnosed at Stereotactic Vacuum-Assisted Breast Biopsy: 9-Versus 11-Gauge
Peter R. Eby, Jennifer E. Ochsner, Wendy B. DeMartini et al
AJR 2009;192:229-234
http://www.ajronline.org/cgi/content/abstract/192/1/229

Image-guided radiofrequency excision biopsy of breast lesions

NICE has been notified about this procedure and will consider it as part of the Institute's work programme.
The Interventional Procedures Advisory Committee (IPAC) will consider this procedure and NICE will issue an Interventional Procedures Consultation Document about its safety and efficacy for 4 weeks public consultation. IPAC will then review the consultation document in the light of comments received and produce a Final Interventional Procedures Document, which will be considered by NICE before guidance is issued to the NHS in England, Wales, Scotland and Northern Ireland.

Cases Journal 2008 1:311 14 November 2008

Surgical approach to primary non-Hodgkin's breast lymphoma: a case report
Neri A, Caruso S, Cerullo G, Lenoci M, Marrelli D, Roviello F
Cases Journal, 2008 1:311 ( 14 November 2008 )
[Abstract] [Provisional PDF]

Cases Journal 2008 1:313 17 November 2008

Case Report
Radiation induced malignant histiocytoma of the contralateral breast following treatment of breast cancer: a case report and review of the literature
Biswas S, Badiuddin F Cases Journal, 2008 1:313 ( 17 November 2008 )
[Abstract] [Provisional PDF]

Annals of Surgery November 2008 Volume 248 Issue 5

Letters to the Editor
895
A Randomized Controlled Clinical Trial on Sentinel Node Lymph Node Dissection Versus Axillary Lymph Node Dissection: A Matter of Technique or Patient Selection?
Amtul R. Carmichael, MD, FRCS

895-896
A Randomized Controlled Clinical Trial on Sentinel Node Lymph Node Dissection Versus Axillary Lymph Node Dissection: A Matter of Technique or Patient Selection?
Giorgio Zavagno, MD

AJR November 2008 Vol. 191 No. 5

Staging MR Lymphangiography of the Axilla for Early Breast Cancer: Cost-Effectiveness Analysis
Pari V. Pandharipande, Mukesh G. Harisinghani, Elissa M. Ozanne et al
AJR 2008;191:1308-1319
http://www.ajronline.org/cgi/content/abstract/191/5/1308
A Brief Commentary on Cost-Effectiveness Analysis in Radiologic Research
Colin S. Poon
AJR 2008;191:1320-1322
http://www.ajronline.org/cgi/content/abstract/191/5/1320
Dual-Time-Point 18F-FDG PET/CT Versus Dynamic Breast MRI of Suspicious Breast Lesions Massimo Imbriaco, Maria Grazia Caprio, Gennaro Limite, Leonardo Pace et al
AJR 2008;191:1323-1330
http://www.ajronline.org/cgi/content/abstract/191/5/1323
Dynamic Contrast-Enhanced MRI for Prediction of Breast Cancer Response to Neoadjuvant Chemotherapy: Initial Results
Claudette E. Loo, H. Jelle Teertstra, Sjoerd Rodenhuis, Marc J. van de Vijver et al
AJR 2008;191:1331-1338
http://www.ajronline.org/cgi/content/abstract/191/5/1331
Contrast-Enhanced MR Mammography: Improved Lesion Detection and Differentiation with Gadobenate Dimeglumine
Federica Pediconi, Carlo Catalano, Simona Padula, Antonella Roselli et al
AJR 2008;191:1339-1346
http://www.ajronline.org/cgi/content/abstract/191/5/1339
Underestimation of Atypical Ductal Hyperplasia at Sonographically Guided Core Biopsy of the Breast
Mijung Jang, Nariya Cho, Woo Kyung Moon, Jeong Seon Park et al
AJR 2008;191:1347-1351
http://www.ajronline.org/cgi/content/abstract/191/5/1347



Letters ----------------------------------------------------------------- Performance Parameters for Mammography Screening Richard L. Ellis AJR 2008;191:204 http://www.ajronline.org/cgi/content/full/191/5/W204 Reply Matthew Gromet AJR 2008;191:205 http://www.ajronline.org/cgi/content/full/191/5/W205

British Journal of Surgery Volume 95 Issue 11 2008

Pages: 1352-1355
False-negative sentinel lymph node biopsy
B. J. van Wely, M. L. Smidt, I. M. de Kievit, C. A. P. Wauters, L. J. A. Strobbe
http://www3.interscience.wiley.com/cgi-bin/abstract/121431164/ABSTRACT
Published Online: 9 Oct 2008
DOI: 10.1002/bjs.6348


Pages: 1356-1361
Development and validation of a model predictive of occult nipple involvement in women undergoing mastectomy
J. E. Rusby, E. F. Brachtel, M. Othus, J. S. Michaelson, F. C. Koerner, B. L. Smith
http://www3.interscience.wiley.com/cgi-bin/abstract/121431167/ABSTRACT
Published Online: 9 Oct 2008
DOI: 10.1002/bjs.6349

Are Community Hospitals Undertreating Breast Cancer?

Link to journal

Gutierrez, Juan C. ; Hurley, Judith D. ; Housri, Nadine ; Perez, Eduardo A. et al
Are Many Community Hospitals Undertreating Breast Cancer?: Lessons From 24,834 Patients
Annals of Surgery. 248(2):154-162, August 2008.
Abstract
Objective: To compare treatment patterns and long-term outcomes between teaching and community hospitals treating patients with infiltrating ductal carcinoma (IDC).Methods: All IDCs from the Florida Cancer Data System from 1994 to 2000 were examined.Results: Overall, 24,834 operative cases of IDC were identified. Teaching hospitals treated 11.3% of patients with a larger proportion of stage III and IV disease (39.8% vs. 33.0%). Five- and 10-year overall survival rates at teaching hospitals were 84% and 72%, compared with 81% and 69% at high-volume community hospitals and 77% and 63% at low-volume hospitals (P < p =" 0.008)." ratio =" 0.763," ratio =" 0.903,">

Histopathology - review issue on breast pathology

The aim of this issue is to provide a range of articles addressing diagnostic, predictive and prognostic breast pathology, as well as some overviews of areas of research that have implications for future developments particularly in targeted clinical therapies. A number of the manuscripts address lesions causing diagnostic difficulties, as evidenced by routine day-today and referral practice, as reported previously in this journal. Reviews of other, commoner lesions have been selected where there have been developments in understanding of the biology or changes in classification.I have found reading and editing the articles in this review issue of Histopathology both illuminating and educational. I hope the readers, similarly, find the selection of topics stimulating and valuable. Sarah E Pinder - Editorial
FREE ACCESS to all articles in this exciting new review issue!

An update on apocrine lesions of the breast

Columnar cell lesions of the breast

Papillary lesions of the breast: selected diagnostic and management issues

Vascular proliferations of the breast

Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast

In situ and invasive lobular neoplasia of the breast

Expression profiling technology: its contribution to our understanding of breast cancer

Predictive markers in breast cancer - the present

Predictive markers in breast cancer - the future

Stem cells and breast cancerTriple negative tumours: a critical review