Ribociclib plus letrozole inearly breast cancer: A presurgical, window-of-opportunity study
The Breast August 2016 Volume 28, Pages 191–198
Curigliano G et al
Cyclin D–cyclin-dependent kinase (CDK) 4/6–inhibitor of
CDK4/6–retinoblastoma (Rb) pathway hyperactivation is associated with hormone
receptor-positive (HR+) breast cancer (BC). This study assessed the biological
activity of ribociclib (LEE011; CDK4/6 inhibitor) plus letrozole compared with
single-agent letrozole in the presurgical setting.
Positive margins prediction in
breast cancer conservative surgery: Assessment of a preoperative web-based
nomogram
The Breast August 2016 Volume 28, Pages 167–173
Alves-Ribeiro L et al
Margin status of the surgical specimen has been shown to be a
prognostic and risk factor for local recurrence in breast cancer surgery. It
has been studied as a topic of intervention to diminish reoperation rates and
reduce the probability of local recurrence in breast conservative surgery
(BCS).This study aims to validate the Dutch Breast Conservation nomogram,
created by Pleijhus et al., which predicts preoperative probability of
positive margins in BCS.Patients with diagnosis of breast cancer stages cT1-2,
who underwent BCS at the Breast Center of São João University Hospital
(BC-CHSJ) in 2013–2014, were included.
Five-year results of aprospective clinical trial investigating accelerated partial breast irradiation using 3D conformal radiotherapy after lumpectomy for early stage breast cancer
The Breast August 2016 Volume 28, Pages 178–183
Horst KC et al
Accelerated partial breast irradiation (APBI) is emerging as
an alternative to whole-breast irradiation. This study presents the results of
a prospective trial evaluating 3-dimensional conformal radiotherapy (3D-CRT) to
deliver APBI for early-stage breast cancer.
Decision making, psychologicalwellbeing and psychosocial outcomes for high risk women who choose to undergobilateral prophylactic mastectomy – A review of the literature
The Breast August 2016 Volume 28, Pages 130–135
Glassey R, Ives
A, Saunders C, Musiello T
A bilateral prophylactic, or preventative, mastectomy (BPM)
for women at high risk of developing breast cancer (BC) can reduce their risk
of developing the disease by up to 90% (relative risk reduction). An increasing
number of women, including young women, are taking up this option. However,
there is a dearth of information for younger women (under 40 years) choosing
preventative mastectomy. In fact, no studies to date have specifically focused
on younger women's experiences of a BPM and investigated their informational
needs.
Chemotherapy port related
lymphedema after axillary lymph node dissection
The Breast August 2016 Volume 28, Pages 145–147
Turfe Z et al
The Mascagni lymphatic pathway comprises superficial channels
along the clavicle that drain upper extremity lymph. A 65 year-old woman with
recurrent left breast cancer presented with a non-functioning chemotherapy port
in the right deltopectoral groove. She had undergone right mastectomy with
axillary lymph node dissection (ALND). After port removal and wound closure she
developed right upper extremity lymphedema. Patients who have undergone ALND
may depend solely on this pathway for upper extremity lymphatic drainage.
